Somatosensory Brain Function and Gray Matter Regional Volumes Differ According to Exercise History : Evidence from Monozygotic Twins

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dc.contributor.author Hautasaari, Pekka
dc.contributor.author Savic, Andrej M.
dc.contributor.author Loberg, Otto
dc.contributor.author Niskanen, Eini
dc.contributor.author Kaprio, Jaakko
dc.contributor.author Kujala, Urho M.
dc.contributor.author Tarkka, Ina M.
dc.date.accessioned 2018-02-18T22:10:41Z
dc.date.available 2021-12-17T18:49:39Z
dc.date.issued 2017-01
dc.identifier.citation Hautasaari , P , Savic , A M , Loberg , O , Niskanen , E , Kaprio , J , Kujala , U M & Tarkka , I M 2017 , ' Somatosensory Brain Function and Gray Matter Regional Volumes Differ According to Exercise History : Evidence from Monozygotic Twins ' , Brain Topography , vol. 30 , no. 1 , pp. 77-86 . https://doi.org/10.1007/s10548-016-0531-1
dc.identifier.other PURE: 80080378
dc.identifier.other PURE UUID: 5b51acc3-a53f-4245-a17a-00ff81c16ee2
dc.identifier.other WOS: 000392068500006
dc.identifier.other Scopus: 84991821846
dc.identifier.uri http://hdl.handle.net/10138/232550
dc.description.abstract Associations between long-term physical activity and cortical function and brain structure are poorly known. Our aim was to assess whether brain functional and/or structural modulation associated with long-term physical activity is detectable using a discordant monozygotic male twin pair design. Nine monozygotic male twin pairs were carefully selected for an intrapair difference in their leisure-time physical activity of at least three years duration (mean age 34 +/- 1 years). We registered somatosensory mismatch response (SMMR) in EEG to electrical stimulation of fingers and whole brain MR images. We obtained exercise history and measured physical fitness and body composition. Equivalent electrical dipole sources of SMMR as well as gray matter (GM) voxel counts in regions of interest indicated by source analysis were evaluated. SMMR dipolar source strengths differed between active and inactive twins within twin pairs in postcentral gyrus, medial frontal gyrus and superior temporal gyrus and in anterior cingulate (AC) GM voxel counts differed similarly. Compared to active twins, their inactive twin brothers showed greater dipole strengths in short periods of the deviant-elicited SMMR and larger AC GM voxel counts. Stronger activation in early unattended cortical processing of the deviant sensory signals in inactive co-twins may imply less effective gating of somatosensory information in inactive twins compared to their active brothers. Present findings indicate that already in 30's long-term physical activity pattern is linked with specific brain indices, both in functional and structural domains. en
dc.format.extent 10
dc.language.iso eng
dc.relation.ispartof Brain Topography
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject Twin research
dc.subject Brain electrophysiology
dc.subject Somatosensory cortex
dc.subject Mismatch negativity
dc.subject Brain structure
dc.subject Physical activity
dc.subject MISMATCH NEGATIVITY MMN
dc.subject TIME PHYSICAL-ACTIVITY
dc.subject DISCRIMINATION
dc.subject RESPONSES
dc.subject HEALTH
dc.subject EXCITABILITY
dc.subject GENERATORS
dc.subject POTENTIALS
dc.subject MODULATION
dc.subject FITNESS
dc.subject 3142 Public health care science, environmental and occupational health
dc.title Somatosensory Brain Function and Gray Matter Regional Volumes Differ According to Exercise History : Evidence from Monozygotic Twins en
dc.type Article
dc.contributor.organization Clinicum
dc.contributor.organization Institute for Molecular Medicine Finland
dc.contributor.organization Jaakko Kaprio / Principal Investigator
dc.contributor.organization Department of Public Health
dc.contributor.organization Genetic Epidemiology
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1007/s10548-016-0531-1
dc.relation.issn 0896-0267
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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