Demographic associations for autoantibodies in disease-free individuals of a European population

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http://hdl.handle.net/10138/232830

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Haller-Kikkatalo , K , Alnek , K , Metspalu , A , Mihailov , E , Metskula , K , Kisand , K , Pisarev , H , Salumets , A & Uibo , R 2017 , ' Demographic associations for autoantibodies in disease-free individuals of a European population ' , Scientific Reports , vol. 7 , 44846 . https://doi.org/10.1038/srep44846

Title: Demographic associations for autoantibodies in disease-free individuals of a European population
Author: Haller-Kikkatalo, Kadri; Alnek, Kristi; Metspalu, Andres; Mihailov, Evelin; Metskula, Kaja; Kisand, Kalle; Pisarev, Heti; Salumets, Andres; Uibo, Raivo
Contributor: University of Helsinki, Department of Obstetrics and Gynecology
Date: 2017-03-28
Language: eng
Number of pages: 12
Belongs to series: Scientific Reports
ISSN: 2045-2322
URI: http://hdl.handle.net/10138/232830
Abstract: The presence of autoantibodies usually precedes autoimmune disease, but is sometimes considered an incidental finding with no clinical relevance. The prevalence of immune-mediated diseases was studied in a group of individuals from the Estonian Genome Project (n = 51,862), and 6 clinically significant autoantibodies were detected in a subgroup of 994 (auto) immune-mediated disease-free individuals. The overall prevalence of individuals with immune-mediated diseases in the primary cohort was 30.1%. Similarly, 23.6% of the participants in the disease-free subgroup were seropositive for at least one autoantibody. Several phenotypic parameters were associated with autoantibodies. The results suggest that (i) immune-mediated diseases are diagnosed in nearly one-third of a random European population, (ii) 6 common autoantibodies are detectable in almost one-third of individuals without diagnosed autoimmune diseases, (iii) tissue non-specific autoantibodies, especially at high levels, may reflect preclinical disease in symptom-free individuals, and (iv) the incidental positivity of anti-TPO in men with positive familial anamnesis of maternal autoimmune disease deserves further medical attention. These results encourage physicians to evaluate autoantibodies in addition to treating a variety of patient health complaints to detect autoimmune-mediated disease early.
Subject: SYSTEMIC-LUPUS-ERYTHEMATOSUS
CELIAC-DISEASE
THYROID-DISORDERS
HIGH PREVALENCE
ANTITHYROID PEROXIDASE
ANTIBODIES
ADULTS
AUTOIMMUNITY
DIAGNOSIS
AWARENESS
3111 Biomedicine
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