Neuroticism Associates with Cerebral in Vivo Serotonin Transporter Binding Differently in Males and Females

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dc.contributor.author Tuominen, Lauri
dc.contributor.author Miettunen, Jouko
dc.contributor.author Cannon, Dara M.
dc.contributor.author Drevets, Wayne C.
dc.contributor.author Frokjaer, Vibe G.
dc.contributor.author Hirvonen, Jussi
dc.contributor.author Ichise, Masanori
dc.contributor.author Jensen, Peter S.
dc.contributor.author Keltikangas-Järvinen, Liisa
dc.contributor.author Klaver, Jacqueline M.
dc.contributor.author Knudsen, Gitte M.
dc.contributor.author Takano, Akihiro
dc.contributor.author Suhara, Tetsuya
dc.contributor.author Hietala, Jarmo
dc.date.accessioned 2018-02-26T10:02:02Z
dc.date.available 2018-02-26T10:02:02Z
dc.date.issued 2017-12
dc.identifier.citation Tuominen , L , Miettunen , J , Cannon , D M , Drevets , W C , Frokjaer , V G , Hirvonen , J , Ichise , M , Jensen , P S , Keltikangas-Järvinen , L , Klaver , J M , Knudsen , G M , Takano , A , Suhara , T & Hietala , J 2017 , ' Neuroticism Associates with Cerebral in Vivo Serotonin Transporter Binding Differently in Males and Females ' , International Journal of Neuropsychopharmacology , vol. 20 , no. 12 , pp. 963-970 . https://doi.org/10.1093/ijnp/pyx071
dc.identifier.other PURE: 99503432
dc.identifier.other PURE UUID: ddc921e8-bfe9-4c92-9f30-d1cc7b61d260
dc.identifier.other WOS: 000423282500002
dc.identifier.other Scopus: 85041255118
dc.identifier.other ORCID: /0000-0002-7977-3852/work/42135346
dc.identifier.uri http://hdl.handle.net/10138/232897
dc.description.abstract Background: Neuroticism is a major risk factor for affective disorders. This personality trait has been hypothesized to associate with synaptic availability of the serotonin transporter, which critically controls serotonergic tone in the brain. However, earlier studies linking neuroticism and serotonin transporter have failed to produce converging findings. Because sex affects both the serotonergic system and the risk that neuroticism poses to the individual, sex may modify the association between neuroticism and serotonin transporter, but this question has not been investigated by previous studies. Methods: Here, we combined data from 4 different positron emission tomography imaging centers to address whether neuroticism is related to serotonin transporter binding in vivo. The data set included serotonin transporter binding potential values from the thalamus and striatum and personality scores from 91 healthy males and 56 healthy females. We specifically tested if the association between neuroticism and serotonin transporter is different in females and males. Results: We found that neuroticism and thalamic serotonin transporter binding potentials were associated in both males and females, but with opposite directionality. Higher neuroticism associated with higher serotonin transporter binding potential in males (standardized beta 0.292, P = .008), whereas in females, higher neuroticism associated with lower serotonin transporter binding potential (standardized beta -0.288, P = .014). Conclusions: The finding is in agreement with recent studies showing that the serotonergic system is involved in affective disorders differently in males and females and suggests that contribution of thalamic serotonin transporter to the risk of affective disorders depends on sex. en
dc.format.extent 8
dc.language.iso eng
dc.relation.ispartof International Journal of Neuropsychopharmacology
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject neuroticism
dc.subject sex
dc.subject serotonin
dc.subject serotonin transporter
dc.subject PET
dc.subject POSITRON-EMISSION-TOMOGRAPHY
dc.subject MAJOR DEPRESSIVE DISORDER
dc.subject TEST-RETEST REPRODUCIBILITY
dc.subject POPULATION-BASED TWIN
dc.subject 2A RECEPTOR-BINDING
dc.subject BODY-MASS INDEX
dc.subject HUMAN BRAIN
dc.subject GENDER-DIFFERENCES
dc.subject HEALTHY-SUBJECTS
dc.subject POSTMENOPAUSAL WOMEN
dc.subject 515 Psychology
dc.subject 3112 Neurosciences
dc.subject 3141 Health care science
dc.title Neuroticism Associates with Cerebral in Vivo Serotonin Transporter Binding Differently in Males and Females en
dc.type Article
dc.contributor.organization Department of Psychology and Logopedics
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1093/ijnp/pyx071
dc.relation.issn 1461-1457
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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