Fatigue and disturbances of sleep in patients with osteogenesis imperfecta - a cross-sectional questionnaire study

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Arponen , H , Waltimo-Siren , J , Valta , H & Mäkitie , O 2018 , ' Fatigue and disturbances of sleep in patients with osteogenesis imperfecta - a cross-sectional questionnaire study ' , BMC Musculoskeletal Disorders , vol. 19 , 3 . https://doi.org/10.1186/s12891-017-1922-5

Title: Fatigue and disturbances of sleep in patients with osteogenesis imperfecta - a cross-sectional questionnaire study
Author: Arponen, Heidi; Waltimo-Siren, Janna; Valta, Helena; Mäkitie, Outi
Other contributor: University of Helsinki, Department of Oral and Maxillofacial Diseases
University of Helsinki, Clinicum
University of Helsinki, Children's Hospital
University of Helsinki, Clinicum







Date: 2018-01-08
Language: eng
Number of pages: 7
Belongs to series: BMC Musculoskeletal Disorders
ISSN: 1471-2474
DOI: https://doi.org/10.1186/s12891-017-1922-5
URI: http://hdl.handle.net/10138/233122
Abstract: Background: Persisting fatigue has been reported to be a common complaint by individuals with connective tissue disorders, including Osteogenesis imperfecta (OI). This controlled study evaluated in an adult OI population the subjective experience of fatigue, affecting daily life. Sleep disturbances and chronic pain were examined as hypothesized underlying factors. Methods: This cross-sectional study analyzed the answers of 56 OI patients and 56 matched healthy controls to a questionnaire, designed to evaluate levels of experienced fatigue and bodily pain, as well as the presence or absence of symptoms related to sleep disturbances or sleep apnea. The relationships between fatigue, pain, and sleep disturbances were evaluated with correlation analysis and regression analysis. Results: Fatigue was reported by 96%, and daily pain by 87% of the individuals with OI. Notably, the level of fatigue was similarly experienced by patient respondents and controls. In total, 95% of the patients and 77% of the controls reported one to several sleep disturbance symptoms. These symptoms as well as previously diagnosed sleep apnea were statistically significantly more prevalent in the patient group than in the controls (p <0.05). Likewise, the experienced bodily pain was statistically highly significantly more severe among the respondents with OI (p <0.001), and correlated with the reported fatigue. Conclusions: In comparison with age-matched controls, adults with OI do not differ in experienced fatigue, unlike hypothesized. Therefore, sleep disturbances, which based on the frequency of reported related symptoms and previous sleep apnea diagnoses appear to be common in OI patients, may remain undiagnosed.
Subject: Osteogenesis imperfecta
Fatigue
Sleep disturbances
Quality of life
QUALITY-OF-LIFE
DAYTIME SLEEPINESS
CHRONIC INSOMNIA
APNEA
CHILDREN
POPULATION
DIAGNOSIS
ADULTS
EPIDEMIOLOGY
ASSOCIATIONS
3126 Surgery, anesthesiology, intensive care, radiology
3121 General medicine, internal medicine and other clinical medicine
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