Dexamethasone in head and neck cancer patients with microvascular reconstruction : No benefit, more complications

Show simple item record Kainulainen, S. Tornwall, J. Koivusalo, A. M. Suominen, A. L. Lassus, Patrik 2018-03-08T22:08:53Z 2021-12-17T18:48:47Z 2017-02
dc.identifier.citation Kainulainen , S , Tornwall , J , Koivusalo , A M , Suominen , A L & Lassus , P 2017 , ' Dexamethasone in head and neck cancer patients with microvascular reconstruction : No benefit, more complications ' , Oral Oncology , vol. 65 , pp. 45-50 .
dc.identifier.other PURE: 80896855
dc.identifier.other PURE UUID: 5f5b5b67-2a76-406e-81b8-47b9f6b286ea
dc.identifier.other WOS: 000392641100009
dc.identifier.other Scopus: 85007385032
dc.description.abstract Objectives: Glucocorticoids are widely used in association with major surgery of the head and neck to improve postoperative rehabilitation, shorten intensive care unit and hospital stay, and reduce neck swelling. This study aimed to clarify whether peri-and postoperative use of dexamethasone in reconstructive head and neck cancer surgery is associated with any advantages or disadvantages. Materials and methods: This prospective double-blind randomized controlled trial comprised 93 patients. A total dose of 60 mg of dexamethasone was administered to 51 patients over three days peri-and post-operatively. The remaining 42 patients served as controls. The main primary outcome variables were neck swelling, length of intensive care unit and hospital stay, duration of intubation or tracheostomy, and delay to start of possible radiotherapy. Complications were also recorded. Results: No statistical differences emerged between the two groups in any of the main primary outcome variables. However, there were more major complications, especially infections, needing secondary surgery within three weeks of the operation in patients receiving dexamethasone than in control patients (27% vs. 7%, p = 0.012). Conclusions: The use of dexamethasone in oral cancer patients with microvascular reconstruction did not provide a benefit. More major complications, especially infections, occurred in patients receiving dexamethasone. Our data thus do not support the use of peri-and postoperative dexamethasone in oropharyngeal cancer patients undergoing microvascular reconstruction. (C) 2016 Elsevier Ltd. All rights reserved. en
dc.format.extent 6
dc.language.iso eng
dc.relation.ispartof Oral Oncology
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject Glucocorticoid
dc.subject Dexamethasone
dc.subject Head and neck cancer
dc.subject Microvascular reconstruction
dc.subject Complications
dc.subject ORAL-CAVITY
dc.subject FREE-FLAP
dc.subject REDUCTION
dc.subject 3122 Cancers
dc.subject 3126 Surgery, anesthesiology, intensive care, radiology
dc.subject 313 Dentistry
dc.title Dexamethasone in head and neck cancer patients with microvascular reconstruction : No benefit, more complications en
dc.type Article
dc.contributor.organization Clinicum
dc.contributor.organization Suu- ja leukakirurgian yksikkö
dc.contributor.organization Oral and Maxillofacial Surgery
dc.contributor.organization Department of Oral and Maxillofacial Diseases
dc.contributor.organization Department of Diagnostics and Therapeutics
dc.contributor.organization Anestesiologian yksikkö
dc.contributor.organization Department of Surgery
dc.contributor.organization Plastiikkakirurgian yksikkö
dc.contributor.organization HUS Perioperative, Intensive Care and Pain Medicine
dc.contributor.organization HUS Head and Neck Center
dc.contributor.organization HUS Musculoskeletal and Plastic Surgery
dc.description.reviewstatus Peer reviewed
dc.relation.issn 1368-8375
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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