Unsaturated Fatty Acids Affect Quorum Sensing Communication System and Inhibit Motility and Biofilm Formation of Acinetobacter baumannii

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dc.contributor.author Nicol, Marion
dc.contributor.author Alexandre, Stephane
dc.contributor.author Luizet, Jean-Baptiste
dc.contributor.author Skogman, Malena
dc.contributor.author Jouenne, Thierry
dc.contributor.author Salcedo, Suzana P.
dc.contributor.author De, Emmanuelle
dc.date.accessioned 2018-03-13T11:35:01Z
dc.date.available 2018-03-13T11:35:01Z
dc.date.issued 2018-01
dc.identifier.citation Nicol , M , Alexandre , S , Luizet , J-B , Skogman , M , Jouenne , T , Salcedo , S P & De , E 2018 , ' Unsaturated Fatty Acids Affect Quorum Sensing Communication System and Inhibit Motility and Biofilm Formation of Acinetobacter baumannii ' , International Journal of Molecular Sciences , vol. 19 , no. 1 , 214 . https://doi.org/10.3390/ijms19010214
dc.identifier.other PURE: 100280483
dc.identifier.other PURE UUID: 24579f70-e493-48e5-828d-8b33d4c820dd
dc.identifier.other WOS: 000424407200211
dc.identifier.other Scopus: 85040616767
dc.identifier.other ORCID: /0000-0001-6742-6522/work/42596922
dc.identifier.uri http://hdl.handle.net/10138/233378
dc.description.abstract The increasing threat of Acinetobacter baumannii as a nosocomial pathogen is mainly due to the occurrence of multidrug-resistant strains that are associated with the real problem of its eradication from hospital wards. The particular ability of this pathogen to form biofilms contributes to its persistence, increases antibiotic resistance, and promotes persistent/device-related infections. We previously demonstrated that virstatin, which is a small organic compound known to decrease virulence of Vibrio cholera via an inhibition of T4-pili expression, displayed very promising activity to prevent A. baumannii biofilm development. Here, we examined the antibiofilm activity of mono-unsaturated chain fatty acids, palmitoleic (PoA), and myristoleic (MoA) acids, presenting similar action on V. cholerae virulence. We demonstrated that PoA and MoA (at 0.02 mg/mL) were able to decrease A. baumannii ATCC 17978 biofilm formation up to 38% and 24%, respectively, presented a biofilm dispersing effect and drastically reduced motility. We highlighted that these fatty acids decreased the expression of the regulator abaR from the LuxIR-type quorum sensing (QS) communication system AbaIR and consequently reduced the N-acyl-homoserine lactone production (AHL). This effect can be countered by addition of exogenous AHLs. Besides, fatty acids may have additional non-targeted effects, independent from QS. Atomic force microscopy experiments probed indeed that PoA and MoA could also act on the initial adhesion process in modifying the material interface properties. Evaluation of fatty acids effect on 22 clinical isolates showed a strain-dependent antibiofilm activity, which was not correlated to hydrophobicity or pellicle formation ability of the tested strains, and suggested a real diversity in cell-to-cell communication systems involved in A. baumannii biofilm formation. en
dc.format.extent 10
dc.language.iso eng
dc.relation.ispartof International Journal of Molecular Sciences
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject palmitoleic acid
dc.subject myristoleic acid
dc.subject biofilm
dc.subject pellicle
dc.subject quorum sensing
dc.subject VIBRIO-CHOLERAE VIRULENCE
dc.subject PSEUDOMONAS-AERUGINOSA
dc.subject STAPHYLOCOCCUS-AUREUS
dc.subject CIS-2-DECENOIC ACID
dc.subject TOXT
dc.subject DIMERIZATION
dc.subject MECHANISMS
dc.subject PATHOGEN
dc.subject SURVIVAL
dc.subject 1182 Biochemistry, cell and molecular biology
dc.subject 116 Chemical sciences
dc.title Unsaturated Fatty Acids Affect Quorum Sensing Communication System and Inhibit Motility and Biofilm Formation of Acinetobacter baumannii en
dc.type Article
dc.contributor.organization Faculty of Pharmacy
dc.contributor.organization Division of Pharmaceutical Biosciences
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.3390/ijms19010214
dc.relation.issn 1422-0067
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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