Origin, evolution, and distribution of the molecular machinery for biosynthesis of sialylated lipooligosaccharide structures in Campylobacter coli

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Culebro , A , Machado , M P , Carrico , J A & Rossi , M 2018 , ' Origin, evolution, and distribution of the molecular machinery for biosynthesis of sialylated lipooligosaccharide structures in Campylobacter coli ' , Scientific Reports , vol. 8 , 3028 . https://doi.org/10.1038/s41598-018-21438-2

Title: Origin, evolution, and distribution of the molecular machinery for biosynthesis of sialylated lipooligosaccharide structures in Campylobacter coli
Author: Culebro, Alejandra; Machado, Miguel P.; Carrico, Joao Andre; Rossi, Mirko
Contributor organization: Mirko Rossi Research Group
Food Hygiene and Environmental Health
Faculty of Veterinary Medicine
Departments of Faculty of Veterinary Medicine
Date: 2018-02-14
Language: eng
Number of pages: 9
Belongs to series: Scientific Reports
ISSN: 2045-2322
DOI: https://doi.org/10.1038/s41598-018-21438-2
URI: http://hdl.handle.net/10138/233387
Abstract: Campylobacter jejuni and Campylobacter coli are the most common cause of bacterial gastroenteritis worldwide. Additionally, C. jejuni is the most common bacterial etiological agent in the autoimmune Guillain-Barre syndrome (GBS). Ganglioside mimicry by C. jejuni lipooligosaccharide (LOS) is the triggering factor of the disease. LOS-associated genes involved in the synthesis and transfer of sialic acid (glycosyltranferases belonging to family GT-42) are essential in C. jejuni to synthesize ganglioside-like LOS. Despite being isolated from GBS patients, scarce genetic evidence supports C. coli role in the disease. In this study, through data mining and bioinformatics analysis, C. coli is shown to possess a larger GT-42 glycosyltransferase repertoire than C. jejuni. Although GT-42 glycosyltransferases are widely distributed in C. coli population, only a fraction of C. coli strains (1%) are very likely able to express ganglioside mimics. Even though the activity of C. coli specific GT-42 enzymes and their role in shaping the bacterial population are yet to be explored, evidence presented herein suggest that loss of function of some LOS-associated genes occurred during agriculture niche adaptation.
Subject: GUILLAIN-BARRE-SYNDROME
HIGH-THROUGHPUT
GANGLIOSIDE MIMICS
BACTERIAL PATHOGEN
JEJUNI
HOST
ANNOTATION
DIVERSITY
OLIGOSACCHARIDE
VISUALIZATION
1183 Plant biology, microbiology, virology
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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