HHV-6 in liver transplantation : A literature review

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Phan , T L , Lautenschlager , I , Razonable , R R & Munoz , F M 2018 , ' HHV-6 in liver transplantation : A literature review ' , Liver International , vol. 38 , no. 2 , pp. 210-223 . https://doi.org/10.1111/liv.13506

Title: HHV-6 in liver transplantation : A literature review
Author: Phan, Tuan L.; Lautenschlager, Irmeli; Razonable, Raymund R.; Munoz, Flor M.
Contributor: University of Helsinki, Medicum
Date: 2018-02
Language: eng
Number of pages: 14
Belongs to series: Liver International
ISSN: 1478-3223
URI: http://hdl.handle.net/10138/233489
Abstract: Human herpesvirus 6 (HHV-6A and HHV-6B) can cause primary infection or reactivate from latency in liver transplant recipients, which can result in a variety of clinical syndromes, including fever, hepatitis, encephalitis and higher rates of graft dysfunction as well as indirect effects including increased risks of mortality, CMV disease, hepatitis C progression and greater fibrosis scores. Although HHV-6 infection is currently diagnosed by quantifying viral DNA in plasma or blood, biopsy to demonstrate histopathological effects of HHV-6 remains the gold standard for diagnosis of end-organ disease. HHV-6 reactivation may be restricted to the infected organ with no evidence of active infection in the blood. HHV-6 infections in liver transplant patients are mostly asymptomatic, but clinically significant tissue-invasive infections have been treated successfully with ganciclovir, foscarnet or cidofovir. Inherited chromosomally integrated HHV-6 (ciHHV-6), in either the recipient or the donor organ, may create confusion about systemic HHV-6 infection. Recipients with inherited ciHHV-6 may have an increased risk of opportunistic infection and graft rejection. This article reviews the current scientific data on the clinical effects, risk factors, pathogenesis, diagnosis and treatment of HHV-6 infections in liver transplant recipients.
Subject: chromosomally integrated HHV-6 (CIHHV-6)
human herpesvirus 6 (HHV-6)
liver transplantation
HUMAN-HERPESVIRUS 6
HEPATITIS-C VIRUS
POLYMERASE-CHAIN-REACTION
PRIMARY HUMAN-HERPESVIRUS-6 INFECTION
INTEGRATED HUMAN HERPESVIRUS-6
SOLID-ORGAN
CLINICAL-SIGNIFICANCE
DONOR BIOPSIES
RECIPIENTS
CYTOMEGALOVIRUS
3111 Biomedicine
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