JNK1 controls adult hippocampal neurogenesis and imposes cell-autonomous control of anxiety behaviour from the neurogenic niche

Visa fullständig post



Permalänk

http://hdl.handle.net/10138/233496

Citation

Mohammad , H , Marchisella , F , Ortega-Martinez , S , Hollos , P , Eerola , K , Komulainen , E , Kulesskaya , N , Freemantle , E , Fagerholm , V , Savontous , E , Rauvala , H , Peterson , B D , van Praag , H & Coffey , E T 2018 , ' JNK1 controls adult hippocampal neurogenesis and imposes cell-autonomous control of anxiety behaviour from the neurogenic niche ' , Molecular Psychiatry , vol. 23 , no. 2 , pp. 362-374 . https://doi.org/10.1038/mp.2016.203

Titel: JNK1 controls adult hippocampal neurogenesis and imposes cell-autonomous control of anxiety behaviour from the neurogenic niche
Författare: Mohammad, H.; Marchisella, F.; Ortega-Martinez, S.; Hollos, P.; Eerola, K.; Komulainen, E.; Kulesskaya, N.; Freemantle, E.; Fagerholm, V.; Savontous, E.; Rauvala, H.; Peterson, B. D.; van Praag, H.; Coffey, E. T.
Upphovmannens organisation: Neuroscience Center
University of Helsinki
Datum: 2018-02
Språk: eng
Sidantal: 13
Tillhör serie: Molecular Psychiatry
ISSN: 1359-4184
DOI: https://doi.org/10.1038/mp.2016.203
Permanenta länken (URI): http://hdl.handle.net/10138/233496
Abstrakt: Promoting adult hippocampal neurogenesis is expected to induce neuroplastic changes that improve mood and alleviate anxiety. However, the underlying mechanisms remain largely unknown and the hypothesis itself is controversial. Here we show that mice lacking Jnk1, or c-Jun N-terminal kinase (JNK) inhibitor-treated mice, display increased neurogenesis in adult hippocampus characterized by enhanced cell proliferation and survival, and increased maturation in the ventral region. Correspondingly, anxiety behaviour is reduced in a battery of tests, except when neurogenesis is prevented by AraC treatment. Using engineered retroviruses, we show that exclusive inhibition of JNK in adult-born granule cells alleviates anxiety and reduces depressive-like behaviour. These data validate the neurogenesis hypothesis of anxiety. Moreover, they establish a causal role for JNK in the hippocampal neurogenic niche and anxiety behaviour, and advocate targeting of JNK as an avenue for novel therapies against affective disorders.
Subject: N-TERMINAL KINASE
CEREBELLAR GRANULE NEURONS
C-JUN
DENTATE GYRUS
DORSOVENTRAL AXIS
GLUCOCORTICOID-RECEPTOR
MOLECULAR-MECHANISMS
VENTRAL HIPPOCAMPUS
CEREBRAL-ISCHEMIA
MAJOR DEPRESSION
3112 Neurosciences
3124 Neurology and psychiatry
Referentgranskad: Ja
Licens: cc_by_nc_nd
Användningsbegränsning: openAccess
Parallelpublicerad version: publishedVersion


Filer under denna titel

Totalt antal nerladdningar: Laddar...

Filer Storlek Format Granska
mp2016203.pdf 1.343Mb PDF Granska/Öppna

Detta dokument registreras i samling:

Visa fullständig post