JNK1 controls adult hippocampal neurogenesis and imposes cell-autonomous control of anxiety behaviour from the neurogenic niche

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dc.contributor.author Mohammad, H.
dc.contributor.author Marchisella, F.
dc.contributor.author Ortega-Martinez, S.
dc.contributor.author Hollos, P.
dc.contributor.author Eerola, K.
dc.contributor.author Komulainen, E.
dc.contributor.author Kulesskaya, N.
dc.contributor.author Freemantle, E.
dc.contributor.author Fagerholm, V.
dc.contributor.author Savontous, E.
dc.contributor.author Rauvala, H.
dc.contributor.author Peterson, B. D.
dc.contributor.author van Praag, H.
dc.contributor.author Coffey, E. T.
dc.date.accessioned 2018-03-16T09:01:01Z
dc.date.available 2018-03-16T09:01:01Z
dc.date.issued 2018-02
dc.identifier.citation Mohammad , H , Marchisella , F , Ortega-Martinez , S , Hollos , P , Eerola , K , Komulainen , E , Kulesskaya , N , Freemantle , E , Fagerholm , V , Savontous , E , Rauvala , H , Peterson , B D , van Praag , H & Coffey , E T 2018 , ' JNK1 controls adult hippocampal neurogenesis and imposes cell-autonomous control of anxiety behaviour from the neurogenic niche ' , Molecular Psychiatry , vol. 23 , no. 2 , pp. 362-374 . https://doi.org/10.1038/mp.2016.203
dc.identifier.other PURE: 100445538
dc.identifier.other PURE UUID: fb71212b-b8d5-4284-acd2-6bc7fb9725d7
dc.identifier.other WOS: 000423441700022
dc.identifier.other Scopus: 84995459575
dc.identifier.other ORCID: /0000-0001-5517-8525/work/53517871
dc.identifier.uri http://hdl.handle.net/10138/233496
dc.description.abstract Promoting adult hippocampal neurogenesis is expected to induce neuroplastic changes that improve mood and alleviate anxiety. However, the underlying mechanisms remain largely unknown and the hypothesis itself is controversial. Here we show that mice lacking Jnk1, or c-Jun N-terminal kinase (JNK) inhibitor-treated mice, display increased neurogenesis in adult hippocampus characterized by enhanced cell proliferation and survival, and increased maturation in the ventral region. Correspondingly, anxiety behaviour is reduced in a battery of tests, except when neurogenesis is prevented by AraC treatment. Using engineered retroviruses, we show that exclusive inhibition of JNK in adult-born granule cells alleviates anxiety and reduces depressive-like behaviour. These data validate the neurogenesis hypothesis of anxiety. Moreover, they establish a causal role for JNK in the hippocampal neurogenic niche and anxiety behaviour, and advocate targeting of JNK as an avenue for novel therapies against affective disorders. en
dc.format.extent 13
dc.language.iso eng
dc.relation.ispartof Molecular Psychiatry
dc.rights cc_by_nc_nd
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject N-TERMINAL KINASE
dc.subject CEREBELLAR GRANULE NEURONS
dc.subject C-JUN
dc.subject DENTATE GYRUS
dc.subject DORSOVENTRAL AXIS
dc.subject GLUCOCORTICOID-RECEPTOR
dc.subject MOLECULAR-MECHANISMS
dc.subject VENTRAL HIPPOCAMPUS
dc.subject CEREBRAL-ISCHEMIA
dc.subject MAJOR DEPRESSION
dc.subject 3112 Neurosciences
dc.subject 3124 Neurology and psychiatry
dc.title JNK1 controls adult hippocampal neurogenesis and imposes cell-autonomous control of anxiety behaviour from the neurogenic niche en
dc.type Article
dc.contributor.organization Neuroscience Center
dc.contributor.organization University of Helsinki
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1038/mp.2016.203
dc.relation.issn 1359-4184
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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