Low free 25-hydroxyvitamin D and high vitamin D binding protein and parathyroid hormone in obese Caucasians. A complex association with bone?

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Saarnio , E , Pekkinen , M , Itkonen , S T , Kemi , V , Karp , H , Ivaska , K K , Risteli , J , Koivula , M-K , Kärkkäinen , M , Mäkitie , O , Sievänen , H & Lamberg-Allardt , C 2018 , ' Low free 25-hydroxyvitamin D and high vitamin D binding protein and parathyroid hormone in obese Caucasians. A complex association with bone? ' , PLoS One , vol. 13 , no. 2 , 0192596 . https://doi.org/10.1371/journal.pone.0192596

Title: Low free 25-hydroxyvitamin D and high vitamin D binding protein and parathyroid hormone in obese Caucasians. A complex association with bone?
Author: Saarnio, Elisa; Pekkinen, Minna; Itkonen, Suvi T.; Kemi, Virpi; Karp, Heini; Ivaska, Kaisa K.; Risteli, Juha; Koivula, Marja-Kaisa; Kärkkäinen, Merja; Mäkitie, Outi; Sievänen, Harri; Lamberg-Allardt, Christel
Contributor organization: Department of Food and Nutrition
University of Helsinki
Christel Lamberg-Allardt / Research Group
Clinicum
Children's Hospital
Lastentautien yksikkö
Viikki Molecular Nutrition Group
HUS Children and Adolescents
Date: 2018-02-28
Language: eng
Number of pages: 16
Belongs to series: PLoS One
ISSN: 1932-6203
DOI: https://doi.org/10.1371/journal.pone.0192596
URI: http://hdl.handle.net/10138/233839
Abstract: Background Studies have shown altered vitamin D metabolism in obesity. We assessed differences between obese and normal-weight subjects in total, free, and bioavailable 25-hydroxyvitamin D (25(OH) D, 25(OH) D-Free, and 25(OH) D-Bio, respectively), vitamin D binding protein (DBP), parathyroid hormone (PTH) and bone traits. Methods 595 37-47-year-old healthy Finnish men and women stratified by BMI were examined in this cross-sectional study. Background characteristic and intakes of vitamin D and calcium were collected. The concentrations of 25(OH) D, PTH, DBP, albumin and bone turnover markers were determined from blood. 25(OH) D-Free and 25(OH) D-Bio were calculated. pQCT was performed at radius and tibia. Results Mean +/- SE (ANCOVA) 25(OH) D-Free (10.8 +/- 0.6 vs 12.9 +/- 0.4 nmol/L; P = 0.008) and 25(OH) DBio (4.1 +/- 0.3 vs 5.1 +/- 0.1 nmol/L; P = 0.003) were lower in obese than in normal-weight women. In men, 25(OH) D (48.0 +/- 2.4 vs 56.4 +/- 2.0 nmol/L, P = 0.003), 25(OH) D-Free (10.3 +/- 0.7 vs 12.5 +/- 0.6 pmol/L; P = 0.044) and 25(OH) D-Bio (4.2 +/- 0.3 vs 5.1 +/- 0.2 nmol/L; P = 0.032) were lower in obese. Similarly in all subjects, 25(OH) D, 25(OH) D-Free and 25(OH) D-Bio were lower in obese (P Conclusions The associations between BMI and 25(OH) D, 25(OH) D-Free, and 25(OH) D-Bio, DBP, and PTH suggest that obese subjects may differ from normal-weight subjects in vitamin D metabolism. BMI associated positively with trabecular bone traits and CSI in our study, and slightly negatively with cortical bone traits. Surprisingly, there was a negative association of free and bioavailable 25(OH) D and some of the bone traits in obese women.
Subject: BODY-MASS INDEX
D DEFICIENCY
WOMEN
SERUM
SUPPLEMENTATION
25(OH)D
DENSITY
ADULTS
ASSAYS
MODEL
416 Food Science
3121 General medicine, internal medicine and other clinical medicine
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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