Systematic Review of the Performance of Noninvasive Tests in Diagnosing Bladder Outlet Obstruction in Men with Lower Urinary Tract Symptoms

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Malde , S , Nambiar , A K , Umbach , R , Lam , T B , Bach , T , Bachmann , A , Drake , M J , Gacci , M , Gratzke , C , Madersbacher , S , Mamoulakis , C , Tikkinen , K , Gravas , S & European Assoc Urology Non-neuroge 2017 , ' Systematic Review of the Performance of Noninvasive Tests in Diagnosing Bladder Outlet Obstruction in Men with Lower Urinary Tract Symptoms ' , European Urology , vol. 71 , no. 3 , pp. 391-402 . https://doi.org/10.1016/j.eururo.2016.09.026

Title: Systematic Review of the Performance of Noninvasive Tests in Diagnosing Bladder Outlet Obstruction in Men with Lower Urinary Tract Symptoms
Author: Malde, Sachin; Nambiar, Arjun K.; Umbach, Roland; Lam, Thomas B.; Bach, Thorsten; Bachmann, Alexander; Drake, Marcus J.; Gacci, Mauro; Gratzke, Christian; Madersbacher, Stephan; Mamoulakis, Charalampos; Tikkinen, Kari; Gravas, Stavros; European Assoc Urology Non-neuroge
Other contributor: University of Helsinki, Clinicum




Date: 2017-03
Language: eng
Number of pages: 12
Belongs to series: European Urology
ISSN: 0302-2838
DOI: https://doi.org/10.1016/j.eururo.2016.09.026
URI: http://hdl.handle.net/10138/233866
Abstract: Context: Several noninvasive tests have been developed for diagnosing bladder outlet obstruction (BOO) in men to avoid the burden and morbidity associated with invasive urodynamics. The diagnostic accuracy of these tests, however, remains uncertain. Objective: To systematically review available evidence regarding the diagnostic accuracy of noninvasive tests in diagnosing BOO in men with lower urinary tract symptoms (LUTS) using a pressure-flow study as the reference standard. Evidence acquisition: The EMBASE, MEDLINE, Cochrane Database of Systematic Reviews, Cochrane Central, Google Scholar, and WHO International Clinical Trials Registry Platform Search Portal databases were searched up to May 18, 2016. All studies reporting diagnostic accuracy for noninvasive tests for BOO or detrusor underactivity in men with LUTS compared to pressure-flow studies were included. Two reviewers independently screened all articles, searched the reference lists of retrieved articles, and performed the data extraction. The quality of evidence and risk of bias were assessed using the QUADAS-2 tool. Evidence synthesis: The search yielded 2774 potentially relevant reports. After screening titles and abstracts, 53 reports were retrieved for full-text screening, of which 42 (recruiting a total of 4444 patients) were eligible. Overall, the results were predominantly based on findings from nonrandomised experimental studies and, within the limits of such study designs, the quality of evidence was typically moderate across the literature. Differences in noninvasive test threshold values and variations in the urodynamic definition of BOO between studies limited the comparability of the data. Detrusor wall thickness (median sensitivity 82%, specificity 92%), near- infrared spectroscopy (median sensitivity 85%, specificity 87%), and the penile cuff test (median sensitivity 88%, specificity 75%) were all found to have high sensitivity and specificity in diagnosing BOO. Uroflowmetry with a maximum flow rate of 10 mm was reported to have similar diagnostic accuracy, with median sensitivity of 68% and specificity of 75%. Conclusions: According to the literature, a number of noninvasive tests have high sensitivity and specificity in diagnosing BOO in men. However, although the majority of studies have a low overall risk of bias, the available evidence is limited by heterogeneity. While several tests have shown promising results regarding noninvasive assessment of BOO, invasive urodynamics remain the gold standard. Patient summary: Urodynamics is an accurate but potentially uncomfortable test for patients in diagnosing bladder problems such as obstruction. We performed a thorough and comprehensive review of the literature to determine if there were less uncomfortable but equally effective alternatives to urodynamics for diagnosing bladder problems. We found that some simple tests appear to be promising, although they are not as accurate. Further research is needed before these tests are routinely used in place of urodynamics. (C) 2016 European Association of Urology. Published by Elsevier B.V. All rights reserved.
Subject: Bladder outlet obstruction (BOO)
Men
Lower urinary tract symptoms
Diagnosis
Urodynamics
Noninvasive
Systematic review
NEAR-INFRARED SPECTROSCOPY
INTRAVESICAL PROSTATIC PROTRUSION
COMPRESSION-RELEASE MANEUVER
PENILE CUFF TEST
PRESSURE-FLOW
DOPPLER ULTRASONOGRAPHY
WALL THICKNESS
ULTRASOUND
URODYNAMICS
PARAMETERS
3126 Surgery, anesthesiology, intensive care, radiology
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