DNA methylation holds prognostic information in relapsed precursor B-cell acute lymphoblastic leukemia

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dc.contributor.author Borssen, Magnus
dc.contributor.author Nordlund, Jessica
dc.contributor.author Haider, Zahra
dc.contributor.author Landfors, Mattias
dc.contributor.author Larsson, Par
dc.contributor.author Kanerva, Jukka
dc.contributor.author Schmiegelow, Kjeld
dc.contributor.author Flaegstad, Trond
dc.contributor.author Jonsson, Olafur Gisli
dc.contributor.author Frost, Britt-Marie
dc.contributor.author Palle, Josefine
dc.contributor.author Forestier, Erik
dc.contributor.author Heyman, Mats
dc.contributor.author Hultdin, Magnus
dc.contributor.author Lonnerholm, Gudmar
dc.contributor.author Degerman, Sofie
dc.date.accessioned 2018-04-05T07:03:00Z
dc.date.available 2018-04-05T07:03:00Z
dc.date.issued 2018-03-05
dc.identifier.citation Borssen , M , Nordlund , J , Haider , Z , Landfors , M , Larsson , P , Kanerva , J , Schmiegelow , K , Flaegstad , T , Jonsson , O G , Frost , B-M , Palle , J , Forestier , E , Heyman , M , Hultdin , M , Lonnerholm , G & Degerman , S 2018 , ' DNA methylation holds prognostic information in relapsed precursor B-cell acute lymphoblastic leukemia ' , Clinical epigenetics , vol. 10 , 31 . https://doi.org/10.1186/s13148-018-0466-3
dc.identifier.other PURE: 103029282
dc.identifier.other PURE UUID: c7ceb383-eff1-4893-b3a4-bdbab8f12d67
dc.identifier.other WOS: 000427080200001
dc.identifier.other Scopus: 85043307665
dc.identifier.uri http://hdl.handle.net/10138/233930
dc.description.abstract Background: Few biological markers are associated with survival after relapse of B-cell precursor acute lymphoblastic leukemia (BCP-ALL). In pediatric T-cell ALL, we have identified promoter-associated methylation alterations that correlate with prognosis. Here, the prognostic relevance of CpG island methylation phenotype (CIMP) classification was investigated in pediatric BCP-ALL patients. Methods: Six hundred and one BCP-ALL samples from Nordic pediatric patients (age 1-18) were CIMP classified at initial diagnosis and analyzed in relation to clinical data. Results: Among the 137 patients that later relapsed, patients with a CIMP-profile (n = 42) at initial diagnosis had an inferior overall survival (pOS(5years) 33%) compared to CIMP+ patients (n = 95, pOS(5years) 65%) (p = 0.001), which remained significant in a Cox proportional hazards model including previously defined risk factors. Conclusion: CIMP classification is a strong candidate for improved risk stratification of relapsed BCP-ALL. en
dc.format.extent 7
dc.language.iso eng
dc.relation.ispartof Clinical epigenetics
dc.rights unspecified
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject DNA methylation
dc.subject BCP-ALL
dc.subject Prognosis
dc.subject CIMP
dc.subject Relapse
dc.subject Risk stratification
dc.subject LESSONS
dc.subject 3122 Cancers
dc.title DNA methylation holds prognostic information in relapsed precursor B-cell acute lymphoblastic leukemia en
dc.type Article
dc.contributor.organization Children's Hospital
dc.contributor.organization Lastentautien yksikkö
dc.contributor.organization Clinicum
dc.contributor.organization HUS Children and Adolescents
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1186/s13148-018-0466-3
dc.relation.issn 1868-7083
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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