Body size modifies the relationship between maternal serum 25-hydroxyvitamin D concentrations and gestational diabetes in high-risk women

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Valkama , A J , Meinila , J M , Koivusalo , S B , Lindstrom , J , Rono , K , Tiitinen , A E , Stach-Lempinen , B , Kautiainen , H J , Viljakainen , H , Andersson , S & Eriksson , J G 2018 , ' Body size modifies the relationship between maternal serum 25-hydroxyvitamin D concentrations and gestational diabetes in high-risk women ' , European Journal of Clinical Nutrition , vol. 72 , no. 3 , pp. 460-463 . https://doi.org/10.1038/s41430-017-0010-0

Title: Body size modifies the relationship between maternal serum 25-hydroxyvitamin D concentrations and gestational diabetes in high-risk women
Author: Valkama, Anita J.; Meinila, Jelena M.; Koivusalo, Saila B.; Lindstrom, Jaana; Rono, Kristiina; Tiitinen, Aila E.; Stach-Lempinen, Beata; Kautiainen, Hannu J.; Viljakainen, Heli; Andersson, Sture; Eriksson, Johan G.
Contributor: University of Helsinki, Department of General Practice and Primary Health Care
University of Helsinki, Department of General Practice and Primary Health Care
University of Helsinki, Department of Obstetrics and Gynecology
University of Helsinki, Clinicum
University of Helsinki, Clinicum
University of Helsinki, HYKS erva
University of Helsinki, Clinicum
University of Helsinki, Clinicum
University of Helsinki, HUS Children and Adolescents
University of Helsinki, Department of General Practice and Primary Health Care
Date: 2018-03
Language: eng
Number of pages: 4
Belongs to series: European Journal of Clinical Nutrition
ISSN: 0954-3007
URI: http://hdl.handle.net/10138/233933
Abstract: Obesity increases the risk of low 25-hydroxyvitamin D (25(OH) D) concentrations and gestational diabetes (GDM). We explored whether the association between GDM and change in 25(OH) D concentrations measured in the first (7-18 wk) and second (20-27 wk) trimesters of pregnancy is dependent on maternal BMI. The study was a prospective study of 219 women with BMI of >= 30 kg/m2, a history of GDM, or both. The participants were stratified by first-trimester BMI: BMI of = 35 kg/m(2). In the BMI group >= 35 kg/m(2), those who did not develop GDM during the follow-up showed higher increase in serum 25(OH) D concentrations compared with women who developed GDM (43.2 vs. 11.5%; P <0.001). No associations between 25(OH) D concentrations and GDM were observed in other BMI groups. These findings give an important aspect of the role of maternal body size in the association between vitamin D and GDM in high-risk women.
Subject: CONTROLLED CLINICAL-TRIAL
VITAMIN-D
GLUCOSE-HOMEOSTASIS
DOUBLE-BLIND
SUPPLEMENTATION
MELLITUS
OBESITY
3142 Public health care science, environmental and occupational health
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