Microevolution of bank voles (Myodes glareolus) at neutral and immune-related genes during multiannual dynamic cycles : Consequences for Puumala hantavirus epidemiology

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Dubois , A , Galan , M , Cosson , J-F , Gauffre , B , Henttonen , H , Niemimaa , J , Razzauti , M , Voutilainen , L , Vitalis , R , Guivier , E & Charbonnel , N 2017 , ' Microevolution of bank voles (Myodes glareolus) at neutral and immune-related genes during multiannual dynamic cycles : Consequences for Puumala hantavirus epidemiology ' , Infection, genetics and evolution , vol. 49 , pp. 318-329 . https://doi.org/10.1016/j.meegid.2016.12.007

Title: Microevolution of bank voles (Myodes glareolus) at neutral and immune-related genes during multiannual dynamic cycles : Consequences for Puumala hantavirus epidemiology
Author: Dubois, Adelaide; Galan, Maxime; Cosson, Jean-Francois; Gauffre, Bertrand; Henttonen, Heikki; Niemimaa, Jukka; Razzauti, Maria; Voutilainen, Liina; Vitalis, Renaud; Guivier, Emmanuel; Charbonnel, Nathalie
Contributor organization: Department of Virology
Medicum
Date: 2017-04
Language: eng
Number of pages: 12
Belongs to series: Infection, genetics and evolution
ISSN: 1567-1348
DOI: https://doi.org/10.1016/j.meegid.2016.12.007
URI: http://hdl.handle.net/10138/234004
Abstract: Understanding howhost dynamics, including variations of population size and dispersal, may affect the epidemiology of infectious diseases through ecological and evolutionary processes is an active research area. Here we focus on a bank vole (Myodes glareolus) metapopulation surveyed in Finland between 2005 and 2009. Bank vole is the reservoir of Puumala hantavirus (PUUV), the agent of nephropathia epidemica (NE, a mild form of hemorrhagic fever with renal symptom) in humans. M. glareolus populations experience multiannual density fluctuations that may influence the level of genetic diversity maintained in bank voles, PUUV prevalence and NE occurrence. We examine bank vole metapopulation genetics at presumably neutral markers and immunerelated genes involved in susceptibility to PUUV (Tnf-promoter, Tlr4, Tlr7 and Mx2 gene) to investigate the links between population dynamics, microevolutionary processes and PUUV epidemiology. We show that genetic drift slightly and transiently affects neutral and adaptive genetic variability within the metapopulation. Gene flow seems to counterbalance its effects during the multiannual density fluctuations. The low abundance phase may therefore be too short to impact genetic variation in the host, and consequently viral genetic diversity. Environmental heterogeneity does not seem to affect vole gene flow, which might explain the absence of spatial structure previously detected in PUUV in this area. Besides, our results suggest the role of vole dispersal on PUUV circulation through sex-specific and density-dependent movements. We find little evidence of selection acting on immune-related genes within this metapopulation. Footprint of positive selection is detected at Tlr-4 gene in 2008 only. We observe marginally significant associations between Mx2 genotype and PUUV genogroups. These results show that neutral processes seem to be the main factors affecting the evolution of these immune-related genes at a contemporary scale, although the relative effects of neutral and adaptive forces could vary temporally with density fluctuations. Immune related gene polymorphism may in turn partly influence PUUV epidemiology in this metapopulation. (C) 2016 Published by Elsevier B.V.
Subject: Population genetics
Immunogenetics
Host-pathogen interaction
Density fluctuations
Rodent
Adaptation
NECROSIS-FACTOR-ALPHA
TOLL-LIKE RECEPTORS
EUROPEAN ROE DEER
POPULATION-STRUCTURE
DENSITY-FLUCTUATIONS
NATURAL-POPULATION
MHC DIVERSITY
MX2 PROTEIN
RODENT HOST
SELECTION
3121 General medicine, internal medicine and other clinical medicine
Peer reviewed: Yes
Rights: unspecified
Usage restriction: openAccess
Self-archived version: publishedVersion


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