Peak CK-MB has a strong association with chronic scar size and wall motion abnormalities after revascularized non-transmural myocardial infarction - a prospective CMR study

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Pöyhönen , P , Kylmälä , M , Vesterinen , P , Kivistö , S , Holmström , M , Lauerma , K , Väänänen , H , Toivonen , L & Hänninen , H 2018 , ' Peak CK-MB has a strong association with chronic scar size and wall motion abnormalities after revascularized non-transmural myocardial infarction - a prospective CMR study ' , BMC Cardiovascular Disorders , vol. 18 , 27 . https://doi.org/10.1186/s12872-018-0767-7

Title: Peak CK-MB has a strong association with chronic scar size and wall motion abnormalities after revascularized non-transmural myocardial infarction - a prospective CMR study
Author: Pöyhönen, Pauli; Kylmälä, Minna; Vesterinen, Paula; Kivistö, Sari; Holmström, Miia; Lauerma, Kirsi; Väänänen, Heikki; Toivonen, Lauri; Hänninen, Helena
Other contributor: University of Helsinki, Clinicum
University of Helsinki, HUS Heart and Lung Center
University of Helsinki, Department of Medicine
University of Helsinki, HUS Medical Imaging Center
University of Helsinki, Department of Diagnostics and Therapeutics
University of Helsinki, Clinicum
University of Helsinki, University of Helsinki
University of Helsinki, Department of Medicine







Date: 2018-02-08
Language: eng
Number of pages: 9
Belongs to series: BMC Cardiovascular Disorders
ISSN: 1471-2261
DOI: https://doi.org/10.1186/s12872-018-0767-7
URI: http://hdl.handle.net/10138/234190
Abstract: Background: Large myocardial infarction (MI) is associated with adverse left ventricular (LV) remodeling (LVR). We studied the nature of LVR, with specific attention to non-transmural MIs, and the association of peak CK-MB with recovery and chronic phase scar size and LVR. Methods: Altogether 41 patients underwent prospectively repeated cardiovascular magnetic resonance at a median of 22 (interquartile range 9-29) days and 10 (8-16) months after the first revascularized MI. Transmural MI was defined as >= 75% enhancement in at least one myocardial segment. Results: Peak CK-MB was 86 (40-216) mu g/L in median, while recovery and chronic phase scar size were 13 (3-23) % and 8 (2-19) %. Altogether 33 patients (81%) had a non-transmural MI. Peak CK-MB had a strong correlation with recovery and chronic scar size (r >= 0.80 for all, r >= 0.74 for non-transmural MIs; p <0.001). Peak CK-MB, recovery scar size, and chronic scar size, were all strongly correlated with chronic wall motion abnormality index (WMAi) (r >= 0.75 for all, r >= 0.73 for non-transmural MIs; p <0.001). There was proportional scar size and LV mass resorption of 26% (0-50%) and 6% (-2-14%) in median. Young age (<60 years, median) was associated with greater LV mass resorption (median 9% vs. 1%, p = 0.007). Conclusions: Peak CK-MB has a strong association with chronic scar size and wall motion abnormalities after revascularized non-transmural MI. Considerable infarct resorption happens after the first-month recovery phase. LV mass resorption is related to age, being more common in younger patients.
Subject: Coronary artery disease
Acute myocardial infarction
Infarct transmurality
Left ventricular remodeling
Cardiovascular magnetic resonance
Creatine kinase-MB
CARDIAC MAGNETIC-RESONANCE
VENTRICULAR EJECTION FRACTION
SYSTOLIC VOLUME INDEX
DYSFUNCTION
REPERFUSION
UTILITY
HEART
3121 General medicine, internal medicine and other clinical medicine
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