Percutaneous posterolateral approach for the simulation of a far-lateral disc herniation in an ovine model

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http://hdl.handle.net/10138/234229

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Schwan , S , Ludtka , C , Wiesner , I , Baerthel , A , Friedmann , A & Göhre , F 2018 , ' Percutaneous posterolateral approach for the simulation of a far-lateral disc herniation in an ovine model ' , European Spine Journal , vol. 27 , no. 1 , pp. 222-230 . https://doi.org/10.1007/s00586-017-5362-6

Title: Percutaneous posterolateral approach for the simulation of a far-lateral disc herniation in an ovine model
Author: Schwan, Stefan; Ludtka, Christopher; Wiesner, Ingo; Baerthel, Andre; Friedmann, Andrea; Göhre, Felix
Contributor organization: Clinicum
Department of Neurosciences
Neurokirurgian yksikkö
University of Helsinki
HUS Neurocenter
Date: 2018-01
Language: eng
Number of pages: 9
Belongs to series: European Spine Journal
ISSN: 0940-6719
DOI: https://doi.org/10.1007/s00586-017-5362-6
URI: http://hdl.handle.net/10138/234229
Abstract: This work describes a minimally invasive damage model for ovine lumbar discs via partial nucleotomy using a posterolateral approach. Two cadavers were dissected to analyze the percutaneous corridor. Subsequently, 28 ovine had their annulus fibrosus punctured via awl penetration under fluoroscopic control and nucleus pulposus tissue removed via rongeur. Efficacy was assessed by animal morbidity, ease of access to T12-S1 disc spaces, and production of a mechanical injury as verified by discography, radiography, and histology. T12-S1 were accessible with minimal nerve damage morbidity. Scar tissue sealed the disc puncture site in all animals within 6 weeks, withstanding 1 MP of intradiscal pressure. Partial nucleotomy led to a significant reduction in intervertebral disk height and an increased histological degeneration score. Inducing a reproducible injury pattern of disc degeneration required minimal time, effort, and equipment. The posterolateral approach allows operation on several discs within a single surgery and multiple animal surgeries within a single day.
Subject: Disc herniation
Animal model
Intervertebral disc degeneration
Damage model
Percutaneous surgery
INTERVERTEBRAL DISC
ANNULUS FIBROSUS
ANIMAL-MODEL
DEGENERATION
FAILURE
REGENERATION
ANATOMY
DISEASE
HEIGHT
PAIN
3126 Surgery, anesthesiology, intensive care, radiology
3112 Neurosciences
Peer reviewed: Yes
Usage restriction: openAccess
Self-archived version: publishedVersion


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