Drug Target Commons : A Community Effort to Build a Consensus Knowledge Base for Drug-Target Interactions

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http://hdl.handle.net/10138/234395

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Tang , J , Tanoli , Z-R , Ravikumar , B , Alam , Z , Rebane , A , Vähä-Koskela , M , Peddinti , G , van Adrichem , A J , Wakkinen , J , Jaiswal , A , Karjalainen , E , Gautam , P , He , L , Parri , E , Khan , S , Gupta , A , Ali , M , Yetukuri , L , Gustavsson , A-L , Seashore-Ludlow , B , Hersey , A , Leach , A R , Overington , J P , Repasky , G , Wennerberg , K & Aittokallio , T 2018 , ' Drug Target Commons : A Community Effort to Build a Consensus Knowledge Base for Drug-Target Interactions ' , Cell chemical biology , vol. 25 , no. 2 , pp. 224-+ . https://doi.org/10.1016/j.chembiol.2017.11.009

Titel: Drug Target Commons : A Community Effort to Build a Consensus Knowledge Base for Drug-Target Interactions
Författare: Tang, Jing; Tanoli, Zia-ur-Rehman; Ravikumar, Balaguru; Alam, Zaid; Rebane, Anni; Vähä-Koskela, Markus; Peddinti, Gopal; van Adrichem, Arjan J.; Wakkinen, Janica; Jaiswal, Alok; Karjalainen, Ella; Gautam, Prson; He, Liye; Parri, Elina; Khan, Suleiman; Gupta, Abhishekh; Ali, Mehreen; Yetukuri, Laxman; Gustavsson, Anna-Lena; Seashore-Ludlow, Brinton; Hersey, Anne; Leach, Andrew R.; Overington, John P.; Repasky, Gretchen; Wennerberg, Krister; Aittokallio, Tero
Medarbetare: University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Krister Wennerberg / Principal Investigator
University of Helsinki, Tero Aittokallio / Principal Investigator
Datum: 2018-02-15
Språk: eng
Sidantal: 8
Tillhör serie: Cell chemical biology
ISSN: 2451-9448
Permanenta länken (URI): http://hdl.handle.net/10138/234395
Abstrakt: Knowledge of the full target space of bioactive substances, approved and investigational drugs as well as chemical probes, provides important insights into therapeutic potential and possible adverse effects. The existing compound-target bioactivity data resources are often incomparable due to non-standardized and heterogeneous assay types and variability in endpoint measurements. To extract higher value from the existing and future compound target-profiling data, we implemented an open-data web platform, named Drug Target Commons (DTC), which features tools for crowd-sourced compound-target bioactivity data annotation, standardization, curation, and intra-resource integration. We demonstrate the unique value of DTC with several examples related to both drug discovery and drug repurposing applications and invite researchers to join this community effort to increase the reuse and extension of compound bioactivity data.
Subject: DISCOVERY
CANCER
INFORMATION
DATABASE
BINDING
PROBES
TOOL
3111 Biomedicine
1182 Biochemistry, cell and molecular biology
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