Drug Target Commons : A Community Effort to Build a Consensus Knowledge Base for Drug-Target Interactions

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dc.contributor University of Helsinki, Institute for Molecular Medicine Finland en
dc.contributor University of Helsinki, Institute for Molecular Medicine Finland en
dc.contributor University of Helsinki, Institute for Molecular Medicine Finland en
dc.contributor University of Helsinki, Institute for Molecular Medicine Finland en
dc.contributor University of Helsinki, Institute for Molecular Medicine Finland en
dc.contributor University of Helsinki, Institute for Molecular Medicine Finland en
dc.contributor University of Helsinki, Institute for Molecular Medicine Finland en
dc.contributor University of Helsinki, Institute for Molecular Medicine Finland en
dc.contributor University of Helsinki, Institute for Molecular Medicine Finland en
dc.contributor University of Helsinki, Institute for Molecular Medicine Finland en
dc.contributor University of Helsinki, Institute for Molecular Medicine Finland en
dc.contributor University of Helsinki, Institute for Molecular Medicine Finland en
dc.contributor University of Helsinki, Institute for Molecular Medicine Finland en
dc.contributor University of Helsinki, Institute for Molecular Medicine Finland en
dc.contributor University of Helsinki, Institute for Molecular Medicine Finland en
dc.contributor University of Helsinki, Institute for Molecular Medicine Finland en
dc.contributor University of Helsinki, Institute for Molecular Medicine Finland en
dc.contributor University of Helsinki, Krister Wennerberg / Principal Investigator en
dc.contributor University of Helsinki, Tero Aittokallio / Principal Investigator en
dc.contributor.author Tang, Jing
dc.contributor.author Tanoli, Zia-ur-Rehman
dc.contributor.author Ravikumar, Balaguru
dc.contributor.author Alam, Zaid
dc.contributor.author Rebane, Anni
dc.contributor.author Vähä-Koskela, Markus
dc.contributor.author Peddinti, Gopal
dc.contributor.author van Adrichem, Arjan J.
dc.contributor.author Wakkinen, Janica
dc.contributor.author Jaiswal, Alok
dc.contributor.author Karjalainen, Ella
dc.contributor.author Gautam, Prson
dc.contributor.author He, Liye
dc.contributor.author Parri, Elina
dc.contributor.author Khan, Suleiman
dc.contributor.author Gupta, Abhishekh
dc.contributor.author Ali, Mehreen
dc.contributor.author Yetukuri, Laxman
dc.contributor.author Gustavsson, Anna-Lena
dc.contributor.author Seashore-Ludlow, Brinton
dc.contributor.author Hersey, Anne
dc.contributor.author Leach, Andrew R.
dc.contributor.author Overington, John P.
dc.contributor.author Repasky, Gretchen
dc.contributor.author Wennerberg, Krister
dc.contributor.author Aittokallio, Tero
dc.date.accessioned 2018-04-18T07:52:01Z
dc.date.available 2018-04-18T07:52:01Z
dc.date.issued 2018-02-15
dc.identifier.citation Tang , J , Tanoli , Z-R , Ravikumar , B , Alam , Z , Rebane , A , Vähä-Koskela , M , Peddinti , G , van Adrichem , A J , Wakkinen , J , Jaiswal , A , Karjalainen , E , Gautam , P , He , L , Parri , E , Khan , S , Gupta , A , Ali , M , Yetukuri , L , Gustavsson , A-L , Seashore-Ludlow , B , Hersey , A , Leach , A R , Overington , J P , Repasky , G , Wennerberg , K & Aittokallio , T 2018 , ' Drug Target Commons : A Community Effort to Build a Consensus Knowledge Base for Drug-Target Interactions ' , Cell chemical biology , vol. 25 , no. 2 , pp. 224-+ . https://doi.org/10.1016/j.chembiol.2017.11.009 en
dc.identifier.issn 2451-9448
dc.identifier.other PURE: 104574900
dc.identifier.other PURE UUID: 4fa33441-781c-4404-ba27-d953865d3989
dc.identifier.other WOS: 000425281100014
dc.identifier.other Scopus: 85038839435
dc.identifier.other ORCID: /0000-0002-0886-9769/work/43956535
dc.identifier.other ORCID: /0000-0002-9144-5421/work/53517186
dc.identifier.other ORCID: /0000-0003-0500-533X/work/53827468
dc.identifier.other ORCID: /0000-0001-7480-7710/work/99889547
dc.identifier.uri http://hdl.handle.net/10138/234395
dc.description.abstract Knowledge of the full target space of bioactive substances, approved and investigational drugs as well as chemical probes, provides important insights into therapeutic potential and possible adverse effects. The existing compound-target bioactivity data resources are often incomparable due to non-standardized and heterogeneous assay types and variability in endpoint measurements. To extract higher value from the existing and future compound target-profiling data, we implemented an open-data web platform, named Drug Target Commons (DTC), which features tools for crowd-sourced compound-target bioactivity data annotation, standardization, curation, and intra-resource integration. We demonstrate the unique value of DTC with several examples related to both drug discovery and drug repurposing applications and invite researchers to join this community effort to increase the reuse and extension of compound bioactivity data. en
dc.format.extent 8
dc.language.iso eng
dc.relation.ispartof Cell chemical biology
dc.rights en
dc.subject DISCOVERY en
dc.subject CANCER en
dc.subject INFORMATION en
dc.subject DATABASE en
dc.subject BINDING en
dc.subject PROBES en
dc.subject TOOL en
dc.subject 3111 Biomedicine en
dc.subject 1182 Biochemistry, cell and molecular biology en
dc.title Drug Target Commons : A Community Effort to Build a Consensus Knowledge Base for Drug-Target Interactions en
dc.type Article
dc.description.version Peer reviewed
dc.identifier.doi https://doi.org/10.1016/j.chembiol.2017.11.009
dc.type.uri info:eu-repo/semantics/other
dc.type.uri info:eu-repo/semantics/publishedVersion
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