Stukenborg , J-B , Jahnukainen , K , Hutka , M & Mitchell , R T 2018 , ' Cancer treatment in childhood and testicular function : the importance of the somatic environment ' , Endocrine Connections , vol. 7 , no. 2 , pp. R69-R87 . https://doi.org/10.1530/EC-17-0382
Title: | Cancer treatment in childhood and testicular function : the importance of the somatic environment |
Author: | Stukenborg, Jan-Bernd; Jahnukainen, Kirsi; Hutka, Marsida; Mitchell, Rod T. |
Contributor organization: | Children's Hospital Clinicum University of Helsinki Hematologian yksikkö Department of Oncology HUS Children and Adolescents |
Date: | 2018-02-01 |
Language: | eng |
Number of pages: | 19 |
Belongs to series: | Endocrine Connections |
ISSN: | 2049-3614 |
DOI: | https://doi.org/10.1530/EC-17-0382 |
URI: | http://hdl.handle.net/10138/234400 |
Abstract: | Testicular function and future fertility may be affected by cancer treatment during childhood. Whilst survival of the germ (stem) cells is critical for ensuring the potential for fertility in these patients, the somatic cell populations also play a crucial role in providing a suitable environment to support germ cell maintenance and subsequent development. Regulation of the spermatogonial germ-stem cell niche involves many signalling pathways with hormonal influence from the hypothalamo-pituitary-gonadal axis. In this review, we describe the somatic cell populations that comprise the testicular germ-stem cell niche in humans and how they may be affected by cancer treatment during childhood. We also discuss the experimental models that may be utilized to manipulate the somatic environment and report the results of studies that investigate the potential role of somatic cells in the protection of the germ cells in the testis from cancer treatment. |
Subject: |
fertility
testis cancer treatment fertility preservation SPERMATOGONIAL STEM-CELLS IN-VITRO SPERMATOGENESIS MONKEY MACACA-MULATTA FOLLICLE-STIMULATING-HORMONE ACUTE LYMPHOBLASTIC-LEUKEMIA BONE-MARROW-TRANSPLANTATION RECOMBINANT HUMAN FSH SERTOLI-CELLS HUMAN TESTIS FERTILITY PRESERVATION 3121 General medicine, internal medicine and other clinical medicine 3122 Cancers |
Peer reviewed: | Yes |
Rights: | cc_by |
Usage restriction: | openAccess |
Self-archived version: | publishedVersion |
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