Cancer treatment in childhood and testicular function : the importance of the somatic environment

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Stukenborg , J-B , Jahnukainen , K , Hutka , M & Mitchell , R T 2018 , ' Cancer treatment in childhood and testicular function : the importance of the somatic environment ' , Endocrine Connections , vol. 7 , no. 2 , pp. R69-R87 . https://doi.org/10.1530/EC-17-0382

Title: Cancer treatment in childhood and testicular function : the importance of the somatic environment
Author: Stukenborg, Jan-Bernd; Jahnukainen, Kirsi; Hutka, Marsida; Mitchell, Rod T.
Contributor: University of Helsinki, Children's Hospital
Date: 2018-02-01
Language: eng
Number of pages: 19
Belongs to series: Endocrine Connections
ISSN: 2049-3614
URI: http://hdl.handle.net/10138/234400
Abstract: Testicular function and future fertility may be affected by cancer treatment during childhood. Whilst survival of the germ (stem) cells is critical for ensuring the potential for fertility in these patients, the somatic cell populations also play a crucial role in providing a suitable environment to support germ cell maintenance and subsequent development. Regulation of the spermatogonial germ-stem cell niche involves many signalling pathways with hormonal influence from the hypothalamo-pituitary-gonadal axis. In this review, we describe the somatic cell populations that comprise the testicular germ-stem cell niche in humans and how they may be affected by cancer treatment during childhood. We also discuss the experimental models that may be utilized to manipulate the somatic environment and report the results of studies that investigate the potential role of somatic cells in the protection of the germ cells in the testis from cancer treatment.
Subject: fertility
testis
cancer treatment
fertility preservation
SPERMATOGONIAL STEM-CELLS
IN-VITRO SPERMATOGENESIS
MONKEY MACACA-MULATTA
FOLLICLE-STIMULATING-HORMONE
ACUTE LYMPHOBLASTIC-LEUKEMIA
BONE-MARROW-TRANSPLANTATION
RECOMBINANT HUMAN FSH
SERTOLI-CELLS
HUMAN TESTIS
FERTILITY PRESERVATION
3121 General medicine, internal medicine and other clinical medicine
3122 Cancers
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