Remarkable improvement in serum 25-hydroxyvitamin levels among hip fracture patients over a 12-year period : a prospective study in South-eastern Finland

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Nurmi-Lüthje , I , Tiihonen , R , Paattiniemi , E -L , Naboulsi , H , Pigg , S , Sarkkinen , H , Kaukonen , J-P , Toivanen , A , Salmio , K , Kataja , M & Lüthje , P 2018 , ' Remarkable improvement in serum 25-hydroxyvitamin levels among hip fracture patients over a 12-year period : a prospective study in South-eastern Finland ' , Osteoporosis International , vol. 29 , no. 4 , pp. 837-845 . https://doi.org/10.1007/s00198-017-4344-1

Title: Remarkable improvement in serum 25-hydroxyvitamin levels among hip fracture patients over a 12-year period : a prospective study in South-eastern Finland
Author: Nurmi-Lüthje, I.; Tiihonen, R.; Paattiniemi, E. -L.; Naboulsi, H.; Pigg, S.; Sarkkinen, H.; Kaukonen, J-P; Toivanen, A.; Salmio, K.; Kataja, M.; Lüthje, P.
Other contributor: University of Helsinki, Clinicum
University of Helsinki, HYKS erva
University of Helsinki, HYKS erva
University of Helsinki, HYKS erva
University of Helsinki, HYKS erva
University of Helsinki, HYKS erva



Date: 2018-04
Language: eng
Number of pages: 9
Belongs to series: Osteoporosis International
ISSN: 0937-941X
DOI: https://doi.org/10.1007/s00198-017-4344-1
URI: http://hdl.handle.net/10138/234449
Abstract: Hypovitaminosis D is a problem among hip fracture patients. In a 1-year cohort study comprising 245 hip fracture patients (mean age of females 81 years and males 78 years) from south-eastern Finland, the mean 25-hydroxyvitamin D [S-25(OH)D] concentration was 73(SD 31) nmol/L. Vitamin D supplementation has been integrated into our current practice. The objectives of this study are to verify vitamin D levels among hip fracture patients and to compare the results with a similar study conducted in the same two hospitals covering the same geographic area 12 years ago. A prospective cohort comprising 245 Caucasian hip fracture patients was enrolled in the study in two acute hospitals in south-eastern Finland (61A degrees N) over a 12-month period in 2015-2016. The S-25(OH)D was measured using 25-hydroxyvitamin D electrochemiluminescence binding assay. The S-25(OH)D concentrations were compared with the corresponding concentrations of a similar cohort analyzed in the same two hospitals 12 years ago. Of the 245 patients, 70% were women with a mean age of 81 (SD 10) years, while the men had a mean age of 78 (SD 12) years (p <0.01). The total mean S-25(OH)D concentration was 73 (SD 31.3) nmol/L. Regional differences were found: 15% in hospital A and 36% in hospital B had a S-25(OH(D level <50 nmol/L, and the mean S-25(OH)D level was 79.2 (SD 31.7) nmol/L in hospital A and 62.4 (SD 27.5) nmol/L in hospital B (p <0.001). No differences were found in S-25(OH)D concentrations by either the place of residence or the time of year. Overall, the percentage of patients with a sufficient vitamin D level (> 50 nmol/L) was remarkably higher in 2015-2016 (77%) than in 2003-2004 (22%). Our results indicate that vitamin D supplementation has been widely integrated into our current practice. However, regional differences were found in the S-25(OH)D concentrations for which the reasons are unknown.
Subject: Cohort
Hip fracture
Prospective study
S-25(OH)D
Vitamin D
VITAMIN-D DEFICIENCY
FOLLOW-UP
SOUTHEASTERN FINLAND
RISK
SUPPLEMENTATION
OSTEOPOROSIS
PREVENTION
SURVIVAL
DECLINE
3121 General medicine, internal medicine and other clinical medicine
3142 Public health care science, environmental and occupational health
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