Abnormal Brain Responses to Action Observation in Complex Regional Pain Syndrome

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dc.contributor.author Hotta, Jaakko
dc.contributor.author Saari, Jukka
dc.contributor.author Koskinen, Miika
dc.contributor.author Hlushchuk, Yevhen
dc.contributor.author Forss, Nina
dc.contributor.author Hari, Riitta
dc.date.accessioned 2018-04-20T21:12:56Z
dc.date.available 2021-12-17T18:48:41Z
dc.date.issued 2017-03
dc.identifier.citation Hotta , J , Saari , J , Koskinen , M , Hlushchuk , Y , Forss , N & Hari , R 2017 , ' Abnormal Brain Responses to Action Observation in Complex Regional Pain Syndrome ' , Journal of Pain , vol. 18 , no. 3 , pp. 255-265 . https://doi.org/10.1016/j.jpain.2016.10.017
dc.identifier.other PURE: 83052464
dc.identifier.other PURE UUID: 91f5224d-bb4e-4b08-b043-86aac0d797c2
dc.identifier.other WOS: 000396803400003
dc.identifier.other Scopus: 85009237731
dc.identifier.other ORCID: /0000-0002-1620-8573/work/89583877
dc.identifier.uri http://hdl.handle.net/10138/234475
dc.description.abstract Patients with complex regional pain syndrome (CRPS) display various abnormalities in central motor function, and their pain is intensified when they perform or just observe motor actions. In this study, we examined the abnormalities of brain responses to action observation in CRPS. We analyzed 3-T functional magnetic resonance images from 13 upper limb CRPS patients (all female, ages 31-58 years) and 13 healthy, age- and sex-matched control subjects. The functional magnetic resonance imaging data were acquired while the subjects viewed brief videos of hand actions shown in the first-person perspective. A pattern-classification analysis was applied to characterize brain areas where the activation pattern differed between CRPS patients and healthy subjects. Brain areas with statistically significant group differences (q <.05, false discovery rate-corrected) included the hand representation area in the sensorimotor cortex, inferior frontal gyrus, secondary somatosensory cortex, inferior parietal lobule, orbitofrontal cortex, and thalamus. Our findings indicate that CRPS impairs action observation by affecting brain areas related to pain processing and motor control. Perspective: This article shows that in CRPS, the observation of others' motor actions induces abnormal neural activity in brain areas essential for sensorimotor functions and pain. These results build the cerebral basis for action-observation impairments in CRPS. (C) 2016 by the American Pain Society en
dc.format.extent 11
dc.language.iso eng
dc.relation.ispartof Journal of Pain
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject Action observation
dc.subject chronic pain
dc.subject CRPS
dc.subject fMRI
dc.subject multivoxel pattern analysis
dc.subject TRANSCRANIAL MAGNETIC STIMULATION
dc.subject REFLEX SYMPATHETIC DYSTROPHY
dc.subject PRIMARY SOMATOSENSORY CORTEX
dc.subject DIAGNOSTIC-CRITERIA
dc.subject CYTOARCHITECTONIC MAPS
dc.subject COGNITIVE CONTROL
dc.subject MOTOR IMAGERY
dc.subject HAND ACTIONS
dc.subject CLASSIFICATION
dc.subject 3112 Neurosciences
dc.subject 3124 Neurology and psychiatry
dc.title Abnormal Brain Responses to Action Observation in Complex Regional Pain Syndrome en
dc.type Article
dc.contributor.organization HUS Neurocenter
dc.contributor.organization Neurologian yksikkö
dc.contributor.organization Clinicum
dc.contributor.organization Department of Neurosciences
dc.contributor.organization University of Helsinki
dc.contributor.organization Medicum
dc.contributor.organization Department of Physiology
dc.contributor.organization Department of Diagnostics and Therapeutics
dc.contributor.organization HUS Medical Imaging Center
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1016/j.jpain.2016.10.017
dc.relation.issn 1526-5900
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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