Mass spectrometry-based proteomic exploration of the human immune system : focus on the inflammasome, global protein secretion, and T cells

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Nyman , T A , Lorey , M B , Cypryk , W & Matikainen , S 2017 , ' Mass spectrometry-based proteomic exploration of the human immune system : focus on the inflammasome, global protein secretion, and T cells ' , Expert review of proteomics. , vol. 14 , no. 5 , pp. 395-407 . https://doi.org/10.1080/14789450.2017.1319768

Title: Mass spectrometry-based proteomic exploration of the human immune system : focus on the inflammasome, global protein secretion, and T cells
Author: Nyman, Tuula A.; Lorey, Martina B.; Cypryk, Wojciech; Matikainen, Sampsa
Contributor: University of Helsinki, Clinicum
University of Helsinki, Clinicum
Date: 2017
Language: eng
Number of pages: 13
Belongs to series: Expert review of proteomics.
ISSN: 1478-9450
URI: http://hdl.handle.net/10138/234525
Abstract: Introduction: The immune system is our defense system against microbial infections and tissue injury, and understanding how it works in detail is essential for developing drugs for different diseases. Mass spectrometry-based proteomics can provide in-depth information on the molecular mechanisms involved in immune responses.Areas covered: Summarized are the key immunology findings obtained with MS-based proteomics in the past five years, with a focus on inflammasome activation, global protein secretion, mucosal immunology, immunopeptidome and T cells. Special focus is on extracellular vesicle-mediated protein secretion and its role in immune responses.Expert commentary: Proteomics is an essential part of modern omics-scale immunology research. To date, MS-based proteomics has been used in immunology to study protein expression levels, their subcellular localization, secretion, post-translational modifications, and interactions in immune cells upon activation by different stimuli. These studies have made major contributions to understanding the molecular mechanisms involved in innate and adaptive immune responses. New developments in proteomics offer constantly novel possibilities for exploring the immune system. Examples of these techniques include mass cytometry and different MS-based imaging approaches which can be widely used in immunology.
Subject: Immune system
mass spectrometry
inflammasome
protein secretion
innate immunity
T cell
HUMAN PRIMARY MACROPHAGES
QUANTITATIVE PROTEOMICS
EXTRACELLULAR VESICLES
ANTIVIRAL IMMUNITY
NLRP3 INFLAMMASOME
PHOSPHOPROTEOME CHARACTERIZATION
PEPTIDE REPERTOIRES
SIGNALING PATHWAYS
ANALYSIS REVEALS
VIRUS-INFECTION
3111 Biomedicine
1182 Biochemistry, cell and molecular biology
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