Nyman , T A , Lorey , M B , Cypryk , W & Matikainen , S 2017 , ' Mass spectrometry-based proteomic exploration of the human immune system : focus on the inflammasome, global protein secretion, and T cells ' , Expert review of proteomics. , vol. 14 , no. 5 , pp. 395-407 . https://doi.org/10.1080/14789450.2017.1319768
Title: | Mass spectrometry-based proteomic exploration of the human immune system : focus on the inflammasome, global protein secretion, and T cells |
Author: | Nyman, Tuula A.; Lorey, Martina B.; Cypryk, Wojciech; Matikainen, Sampsa |
Contributor organization: | Clinicum Reumatologian yksikkö Department of Medicine HUS Internal Medicine and Rehabilitation |
Date: | 2017 |
Language: | eng |
Number of pages: | 13 |
Belongs to series: | Expert review of proteomics. |
ISSN: | 1478-9450 |
DOI: | https://doi.org/10.1080/14789450.2017.1319768 |
URI: | http://hdl.handle.net/10138/234525 |
Abstract: | Introduction: The immune system is our defense system against microbial infections and tissue injury, and understanding how it works in detail is essential for developing drugs for different diseases. Mass spectrometry-based proteomics can provide in-depth information on the molecular mechanisms involved in immune responses.Areas covered: Summarized are the key immunology findings obtained with MS-based proteomics in the past five years, with a focus on inflammasome activation, global protein secretion, mucosal immunology, immunopeptidome and T cells. Special focus is on extracellular vesicle-mediated protein secretion and its role in immune responses.Expert commentary: Proteomics is an essential part of modern omics-scale immunology research. To date, MS-based proteomics has been used in immunology to study protein expression levels, their subcellular localization, secretion, post-translational modifications, and interactions in immune cells upon activation by different stimuli. These studies have made major contributions to understanding the molecular mechanisms involved in innate and adaptive immune responses. New developments in proteomics offer constantly novel possibilities for exploring the immune system. Examples of these techniques include mass cytometry and different MS-based imaging approaches which can be widely used in immunology. |
Subject: |
Immune system
mass spectrometry inflammasome protein secretion innate immunity T cell HUMAN PRIMARY MACROPHAGES QUANTITATIVE PROTEOMICS EXTRACELLULAR VESICLES ANTIVIRAL IMMUNITY NLRP3 INFLAMMASOME PHOSPHOPROTEOME CHARACTERIZATION PEPTIDE REPERTOIRES SIGNALING PATHWAYS ANALYSIS REVEALS VIRUS-INFECTION 3111 Biomedicine 1182 Biochemistry, cell and molecular biology |
Peer reviewed: | Yes |
Usage restriction: | openAccess |
Self-archived version: | acceptedVersion |
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