Mass spectrometry-based proteomic exploration of the human immune system : focus on the inflammasome, global protein secretion, and T cells

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dc.contributor.author Nyman, Tuula A.
dc.contributor.author Lorey, Martina B.
dc.contributor.author Cypryk, Wojciech
dc.contributor.author Matikainen, Sampsa
dc.date.accessioned 2018-04-24T21:13:42Z
dc.date.available 2021-12-17T22:02:48Z
dc.date.issued 2017
dc.identifier.citation Nyman , T A , Lorey , M B , Cypryk , W & Matikainen , S 2017 , ' Mass spectrometry-based proteomic exploration of the human immune system : focus on the inflammasome, global protein secretion, and T cells ' , Expert review of proteomics. , vol. 14 , no. 5 , pp. 395-407 . https://doi.org/10.1080/14789450.2017.1319768
dc.identifier.other PURE: 85301345
dc.identifier.other PURE UUID: 78999ea9-f1b5-4729-a7e5-d1fdb88bae65
dc.identifier.other WOS: 000400795000003
dc.identifier.other Scopus: 85019028086
dc.identifier.other ORCID: /0000-0001-5605-6714/work/33744809
dc.identifier.uri http://hdl.handle.net/10138/234525
dc.description.abstract Introduction: The immune system is our defense system against microbial infections and tissue injury, and understanding how it works in detail is essential for developing drugs for different diseases. Mass spectrometry-based proteomics can provide in-depth information on the molecular mechanisms involved in immune responses.Areas covered: Summarized are the key immunology findings obtained with MS-based proteomics in the past five years, with a focus on inflammasome activation, global protein secretion, mucosal immunology, immunopeptidome and T cells. Special focus is on extracellular vesicle-mediated protein secretion and its role in immune responses.Expert commentary: Proteomics is an essential part of modern omics-scale immunology research. To date, MS-based proteomics has been used in immunology to study protein expression levels, their subcellular localization, secretion, post-translational modifications, and interactions in immune cells upon activation by different stimuli. These studies have made major contributions to understanding the molecular mechanisms involved in innate and adaptive immune responses. New developments in proteomics offer constantly novel possibilities for exploring the immune system. Examples of these techniques include mass cytometry and different MS-based imaging approaches which can be widely used in immunology. en
dc.format.extent 13
dc.language.iso eng
dc.relation.ispartof Expert review of proteomics.
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject Immune system
dc.subject mass spectrometry
dc.subject inflammasome
dc.subject protein secretion
dc.subject innate immunity
dc.subject T cell
dc.subject HUMAN PRIMARY MACROPHAGES
dc.subject QUANTITATIVE PROTEOMICS
dc.subject EXTRACELLULAR VESICLES
dc.subject ANTIVIRAL IMMUNITY
dc.subject NLRP3 INFLAMMASOME
dc.subject PHOSPHOPROTEOME CHARACTERIZATION
dc.subject PEPTIDE REPERTOIRES
dc.subject SIGNALING PATHWAYS
dc.subject ANALYSIS REVEALS
dc.subject VIRUS-INFECTION
dc.subject 3111 Biomedicine
dc.subject 1182 Biochemistry, cell and molecular biology
dc.title Mass spectrometry-based proteomic exploration of the human immune system : focus on the inflammasome, global protein secretion, and T cells en
dc.type Review Article
dc.contributor.organization Clinicum
dc.contributor.organization Reumatologian yksikkö
dc.contributor.organization Department of Medicine
dc.contributor.organization HUS Internal Medicine and Rehabilitation
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1080/14789450.2017.1319768
dc.relation.issn 1478-9450
dc.rights.accesslevel openAccess
dc.type.version acceptedVersion

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