Beta-blocker therapy is not associated with mortality after intracerebral hemorrhage

Show full item record



Permalink

http://hdl.handle.net/10138/234548

Citation

Sykora , M , Putaala , J , Meretoja , A , Tatlisumak , T & Strbian , D 2018 , ' Beta-blocker therapy is not associated with mortality after intracerebral hemorrhage ' , Acta Neurologica Scandinavica , vol. 137 , no. 1 , pp. 105-108 . https://doi.org/10.1111/ane.12817

Title: Beta-blocker therapy is not associated with mortality after intracerebral hemorrhage
Author: Sykora, M.; Putaala, J.; Meretoja, A.; Tatlisumak, T.; Strbian, D.
Other contributor: University of Helsinki, Neurologian yksikkö
University of Helsinki, Department of Neurosciences
University of Helsinki, Neurologian yksikkö
University of Helsinki, Neurologian yksikkö




Date: 2018-01
Language: eng
Number of pages: 4
Belongs to series: Acta Neurologica Scandinavica
ISSN: 0001-6314
DOI: https://doi.org/10.1111/ane.12817
URI: http://hdl.handle.net/10138/234548
Abstract: BackgroundBeta-blocker therapy has been suggested to have neuroprotective properties in the setting of acute stroke; however, the evidence is weak and contradictory. We aimed to examine the effects of pre-admission therapy with beta-blockers (BB) on the mortality following spontaneous intracerebral hemorrhage (ICH). MethodsRetrospective analysis of the Helsinki ICH Study database. ResultsA total of 1013 patients with ICH were included in the analysis. Patients taking BB were significantly older, had a higher premorbid mRS score, had more DNR orders, and more comorbidities as atrial fibrillation, hypertension, diabetes mellitus, ischemic heart disease, and heart failure. After adjustment for age, pre-existing comorbidities, and prior use of antithrombotic and antihypertensive medications, no differences in in-hospital mortality (OR 1.1, 95% CI 0.8-1.7), 12-month mortality (OR 1.3, 95% CI 0.9-1.9), and 3-month mortality (OR 1.2, 95% CI 0.8-1.7) emerged. ConclusionPre-admission use of BB was not associated with mortality after ICH.
Subject: beta-blockers
intracerebral hemorrhage
mortality
outcome
ACUTE ISCHEMIC-STROKE
HEART-RATE
SUBARACHNOID HEMORRHAGE
IMPACT
ADMISSION
COHORT
RISK
3124 Neurology and psychiatry
3112 Neurosciences
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
Sykora_et_al_20 ... urologica_Scandinavica.pdf 349.5Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record