Amyloid and the origin of life : self-replicating catalytic amyloids as prebiotic informational and protometabolic entities

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Maury , C P J 2018 , ' Amyloid and the origin of life : self-replicating catalytic amyloids as prebiotic informational and protometabolic entities ' , Cellular and Molecular Life Sciences , vol. 75 , no. 9 , pp. 1499-1507 . https://doi.org/10.1007/s00018-018-2797-9

Title: Amyloid and the origin of life : self-replicating catalytic amyloids as prebiotic informational and protometabolic entities
Author: Maury, Carl Peter J.
Contributor organization: Clinicum
Date: 2018-05
Language: eng
Number of pages: 9
Belongs to series: Cellular and Molecular Life Sciences
ISSN: 1420-682X
DOI: https://doi.org/10.1007/s00018-018-2797-9
URI: http://hdl.handle.net/10138/234616
Abstract: A crucial stage in the origin of life was the emergence of the first molecular entity that was able to replicate, transmit information, and evolve on the early Earth. The amyloid world hypothesis posits that in the pre-RNA era, information processing was based on catalytic amyloids. The self-assembly of short peptides into beta-sheet amyloid conformers leads to extraordinary structural stability and novel multifunctionality that cannot be achieved by the corresponding nonaggregated peptides. The new functions include self-replication, catalytic activities, and information transfer. The environmentally sensitive template-assisted replication cycles generate a variety of amyloid polymorphs on which evolutive forces can act, and the fibrillar assemblies can serve as scaffolds for the amyloids themselves and for ribonucleotides proteins and lipids. The role of amyloid in the putative transition process from an amyloid world to an amyloid-RNA-protein world is not limited to scaffolding and protection: the interactions between amyloid, RNA, and protein are both complex and cooperative, and the amyloid assemblages can function as protometabolic entities catalyzing the formation of simple metabolite precursors. The emergence of a pristine amyloid-based in-put sensitive, chiroselective, and error correcting information-processing system, and the evolvement of mutualistic networks were, arguably, of essential importance in the dynamic processes that led to increased complexity, organization, compartmentalization, and, eventually, the origin of life.
Subject: Origin-of-life theory
Amyloid world
RNA world
Prion
Molecular evolution
Primordial genetics
RNA WORLD
FIBRIL FORMATION
LIPID-MEMBRANES
NUCLEIC-ACID
SECONDARY NUCLEATION
GELSOLIN PEPTIDES
PRIMORDIAL EARTH
PRION PROTEIN
AMINO-ACIDS
BETA-SHEETS
1182 Biochemistry, cell and molecular biology
3111 Biomedicine
Peer reviewed: Yes
Rights: unspecified
Usage restriction: openAccess
Self-archived version: publishedVersion


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