Human picornaviruses associated with neurological diseases and their neutralization by antibodies

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Anastasina , M , Domanska , A , Palm , K & Butcher , S J 2017 , ' Human picornaviruses associated with neurological diseases and their neutralization by antibodies ' , Journal of General Virology , vol. 98 , no. 6 , pp. 1145-1158 . https://doi.org/10.1099/jgv.0.000780

Title: Human picornaviruses associated with neurological diseases and their neutralization by antibodies
Author: Anastasina, Maria; Domanska, Ausra; Palm, Kaia; Butcher, Sarah Jane
Contributor: University of Helsinki, Institute of Biotechnology
University of Helsinki, Institute of Biotechnology
University of Helsinki, Biosciences
Date: 2017-06
Language: eng
Number of pages: 14
Belongs to series: Journal of General Virology
ISSN: 0022-1317
URI: http://hdl.handle.net/10138/234673
Abstract: Picornaviruses are the most commonly encountered infectious agents in mankind. They typically cause mild infections of the gastrointestinal or respiratory tract, but sometimes also invade the central nervous system. There, they can cause severe diseases with long-term sequelae and even be lethal. The most infamous picornavirus is poliovirus, for which significant epidemics of poliomyelitis were reported from the end of the nineteenth century. A successful vaccination campaign has brought poliovirus close to eradication, but neurological diseases caused by other picornaviruses have increasingly been reported since the late 1990s. In this review we focus on enterovirus 71, coxsackievirus A16, enterovirus 68 and human parechovirus 3, which have recently drawn attention because of their links to severe neurological diseases. We discuss the clinical relevance of these viruses and the primary role of humoral immunity in controlling them, and summarize current knowledge on the neutralization of such viruses by antibodies.
Subject: picornavirus
enterovirus
human parechovirus
neutotropic virus
antibody
CENTRAL-NERVOUS-SYSTEM
HUMAN PARECHOVIRUS TYPE-3
HUMAN ENTEROVIRUS 71
VIRUS-LIKE PARTICLES
COXSACKIEVIRUS A16 INFECTION
CEREBROSPINAL-FLUID SAMPLES
X-LINKED AGAMMAGLOBULINEMIA
POLIOMYELITIS-LIKE DISEASE
MOUTH-DISEASE
RESPIRATORY ILLNESS
1183 Plant biology, microbiology, virology
3111 Biomedicine
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