Cholesterol lowering efficacy of plant stanol ester in a new type of product matrix, a chewable dietary supplement

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Laitinen , K , Gylling , H , Kaipiainen , L , Nissinen , M J & Simonen , P 2017 , ' Cholesterol lowering efficacy of plant stanol ester in a new type of product matrix, a chewable dietary supplement ' , Journal of functional foods , vol. 30 , pp. 119-124 . https://doi.org/10.1016/j.jff.2017.01.012

Title: Cholesterol lowering efficacy of plant stanol ester in a new type of product matrix, a chewable dietary supplement
Author: Laitinen, Kirsi; Gylling, Helena; Kaipiainen, Leena; Nissinen, Markku J.; Simonen, Piia
Contributor organization: Department of Medicine
University of Helsinki
Clinicum
Gastroenterologian yksikkö
Kardiologian yksikkö
HUS Internal Medicine and Rehabilitation
HUS Abdominal Center
Date: 2017-03
Language: eng
Number of pages: 6
Belongs to series: Journal of functional foods
ISSN: 1756-4646
DOI: https://doi.org/10.1016/j.jff.2017.01.012
URI: http://hdl.handle.net/10138/234694
Abstract: Low-density lipoprotein (LDL) cholesterol lowering efficacy of a new type of chewable plant stanol ester food supplement was evaluated in a randomized, double-blind, controlled four-week intervention. The participants (LDL cholesterol > 3 mmol/L) consumed four supplements daily with meals either with (n = 50) or without (n = 53) plant stanol esters. Plant stanol ester supplement (2 g/d plant stanols) lowered LDL cholesterol by 7.6%, serum cholesterol by 4.9%, and non-high density lipoprotein (HDL) cholesterol by 6.6% compared with controls (P <0.003). HDL cholesterol or serum triacylglycerol concentrations were unchanged. The taste of the supplement was considered good/very good by 68% of the responders, and convenience to consume it was considered easy/very easy by 78% of the responders. No side effects were reported. In conclusion, this new type of small-volume chewable plant stanol ester supplement lowered LDL cholesterol concentration in hypercholesterolemic subjects providing a convenient dietary tool to regulate circulating cholesterol levels. (C) 2017 Elsevier Ltd. All rights reserved.
Subject: Dietary supplement
Plant stanol ester
LDL cholesterol
Dietary intervention
PRIMARY HYPERCHOLESTEROLEMIA
MODERATE HYPERCHOLESTEROLEMIA
SERUM-CHOLESTEROL
STEROLS
MEN
METAANALYSIS
ADULTS
TRIAL
WOMEN
3121 General medicine, internal medicine and other clinical medicine
416 Food Science
Peer reviewed: Yes
Usage restriction: openAccess
Self-archived version: publishedVersion


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