Decreasing muscle performance associated with increasing disease activity in patients with rheumatoid arthritis

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http://hdl.handle.net/10138/235199

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Uutela , T I , Kautiainen , H J & Häkkinen , A H 2018 , ' Decreasing muscle performance associated with increasing disease activity in patients with rheumatoid arthritis ' , PLoS One , vol. 13 , no. 4 , 0194917 . https://doi.org/10.1371/journal.pone.0194917

Title: Decreasing muscle performance associated with increasing disease activity in patients with rheumatoid arthritis
Author: Uutela, Toini I.; Kautiainen, Hannu J.; Häkkinen, Arja H.
Other contributor: University of Helsinki, Clinicum

Date: 2018-04-09
Language: eng
Number of pages: 11
Belongs to series: PLoS One
ISSN: 1932-6203
DOI: https://doi.org/10.1371/journal.pone.0194917
URI: http://hdl.handle.net/10138/235199
Abstract: Objectives Increasing evidence suggests that inflammation has a detrimental effect on muscle strength. Our objective was to analyse the association between muscle performance and different disease activity levels in patients with rheumatoid arthritis (RA). Method A total of 199 consecutive outpatients were subject to cross-sectional assessment. Measurements of grip strength, endurance of the upper and lower limbs and trunk strength were combined as a muscle performance composite score (MPCS), using a standardised method. The disease activity for 28 joints (DAS28), radiographs of small joints (Larsen score), rheumatoid factor, body mass index (BMI), comorbidities and anti-rheumatic drugs were verified. Patients questionnaires included sociodemographic information, pain level, global disease activity, the Beck Depression Inventory, the mental and physical component scores of Short Form-36 and physical activity level. Results Of the 199 patients, 36%, 17% and 47% patients had remission, low/moderate and high DAS28, respectively. The patients in remission had significantly shorter disease duration, better parameters in terms of pain, physicians assessment, Larsen, Beck or physical component score of Short Form-36, and they were more physically active than other patients. After adjustments for age, sex, RA duration, radiographs and BMI, the decreasing MPCS associated linearly with the increasing DAS28 activity levels (linearity, P Conclusion Poorer MPCS is clearly associated with higher disease activity in patients with RA. Muscle performance is a modifiable risk factor. The findings suggest evaluating muscle performance in clinical practice as a part of patient care.
Subject: 3121 General medicine, internal medicine and other clinical medicine
BONE-MINERAL DENSITY
PHYSICAL-ACTIVITY
ENERGY-EXPENDITURE
HEALTHY CONTROLS
STRENGTH
WOMEN
INACTIVITY
CACHEXIA
CRITERIA
INDEX
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