Hippocampal Sclerosis in the Oldest Old : A Finnish Population-Based Study

Show full item record



Permalink

http://hdl.handle.net/10138/235228

Citation

Kero , M , Raunio , A , Polvikoski , T , Tienari , P J , Paetau , A & Myllykangas , L 2018 , ' Hippocampal Sclerosis in the Oldest Old : A Finnish Population-Based Study ' , Journal of Alzheimer's Disease , vol. 63 , no. 1 , pp. 263-272 . https://doi.org/10.3233/JAD-171068

Title: Hippocampal Sclerosis in the Oldest Old : A Finnish Population-Based Study
Author: Kero, Mia; Raunio, Anna; Polvikoski, Tuomo; Tienari, Pentti J.; Paetau, Anders; Myllykangas, Liisa
Contributor: University of Helsinki, HUSLAB
University of Helsinki, HUSLAB
University of Helsinki, Clinicum
University of Helsinki, HUSLAB
University of Helsinki, HUSLAB
Date: 2018
Language: eng
Number of pages: 10
Belongs to series: Journal of Alzheimer's Disease
ISSN: 1387-2877
URI: http://hdl.handle.net/10138/235228
Abstract: Background: There are only few population-based studies that have systemically investigated the prevalence of hippocampal sclerosis (HS) in the very old. The frequency of unilateral versus bilateral HS has been rarely studied. Objective: We investigated the prevalence and laterality of HS and its association with other neurodegenerative and vascular pathologies in a population-based sample of very elderly. Furthermore, the concomitant presence of immunoreactivity for TDP-43, p62, and HPtau was studied. Methods: The population-based Vantaa 85(+) study includes all inhabitants of the city of Vantaa, who were > 85 years in 1991 (n = 601). Neuropathological assessment was possible in 302 subjects. Severity of neuronal loss of CA sectors and subiculum was determined bilaterally by HE-staining. Immunohistochemistry performed using antibodies for TDP-43, p62, and HPtau. Results: Neuronal loss and pathological changes in the hippocampus sector CA1 and subiculum were observed in 47 of the 302 individuals (16%), and 51% of these changes were bilateral. HS without comorbid neurodegenerative pathology was found in 1/47 subjects with HS (2%). Dementia (p <0.001) and TDP-43 immunopositivity of the granular cell layer of the dentate fascia (p <0.001) were strongly associated with HS. The CERAD score, immunopositivity for HPtau and p62 in the granular cell layer of the fascia dentate were also associated. Conclusion: HS is prevalent (16%) in the oldest old population, but HS without any comorbid neurodegenerative pathology is rare. The high frequency of unilateral HS (49%) implied that bilateral sampling of hippocampi should be routine practice in neuropathological examination.
Subject: Dementia
hippocampal sclerosis
hippocampal sclerosis without any comorbid neurodegenerative pathology
laterality
population-based
TDP-43
very old
MIMICKING ALZHEIMERS-DISEASE
COMMON PATHOLOGICAL FEATURE
FRONTOTEMPORAL DEMENTIA
TDP-43 IMMUNOREACTIVITY
LEWY BODIES
RARE CAUSE
BRAIN
AGE
ASSOCIATION
DEGENERATION
3112 Neurosciences
3124 Neurology and psychiatry
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
jad171068.pdf 665.3Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record