Hippocampal Sclerosis in the Oldest Old : A Finnish Population-Based Study

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dc.contributor.author Kero, Mia
dc.contributor.author Raunio, Anna
dc.contributor.author Polvikoski, Tuomo
dc.contributor.author Tienari, Pentti J.
dc.contributor.author Paetau, Anders
dc.contributor.author Myllykangas, Liisa
dc.date.accessioned 2018-05-18T10:22:01Z
dc.date.available 2018-05-18T10:22:01Z
dc.date.issued 2018
dc.identifier.citation Kero , M , Raunio , A , Polvikoski , T , Tienari , P J , Paetau , A & Myllykangas , L 2018 , ' Hippocampal Sclerosis in the Oldest Old : A Finnish Population-Based Study ' , Journal of Alzheimer's Disease , vol. 63 , no. 1 , pp. 263-272 . https://doi.org/10.3233/JAD-171068
dc.identifier.other PURE: 106969228
dc.identifier.other PURE UUID: 803b666e-14a4-4449-a648-e55bc143b40c
dc.identifier.other WOS: 000430016100025
dc.identifier.other ORCID: /0000-0003-0356-7048/work/44999242
dc.identifier.other Scopus: 85056269793
dc.identifier.other ORCID: /0000-0002-2237-5466/work/123137829
dc.identifier.uri http://hdl.handle.net/10138/235228
dc.description.abstract Background: There are only few population-based studies that have systemically investigated the prevalence of hippocampal sclerosis (HS) in the very old. The frequency of unilateral versus bilateral HS has been rarely studied. Objective: We investigated the prevalence and laterality of HS and its association with other neurodegenerative and vascular pathologies in a population-based sample of very elderly. Furthermore, the concomitant presence of immunoreactivity for TDP-43, p62, and HPtau was studied. Methods: The population-based Vantaa 85(+) study includes all inhabitants of the city of Vantaa, who were > 85 years in 1991 (n = 601). Neuropathological assessment was possible in 302 subjects. Severity of neuronal loss of CA sectors and subiculum was determined bilaterally by HE-staining. Immunohistochemistry performed using antibodies for TDP-43, p62, and HPtau. Results: Neuronal loss and pathological changes in the hippocampus sector CA1 and subiculum were observed in 47 of the 302 individuals (16%), and 51% of these changes were bilateral. HS without comorbid neurodegenerative pathology was found in 1/47 subjects with HS (2%). Dementia (p <0.001) and TDP-43 immunopositivity of the granular cell layer of the dentate fascia (p <0.001) were strongly associated with HS. The CERAD score, immunopositivity for HPtau and p62 in the granular cell layer of the fascia dentate were also associated. Conclusion: HS is prevalent (16%) in the oldest old population, but HS without any comorbid neurodegenerative pathology is rare. The high frequency of unilateral HS (49%) implied that bilateral sampling of hippocampi should be routine practice in neuropathological examination. en
dc.format.extent 10
dc.language.iso eng
dc.relation.ispartof Journal of Alzheimer's Disease
dc.rights cc_by_nc
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject Dementia
dc.subject hippocampal sclerosis
dc.subject hippocampal sclerosis without any comorbid neurodegenerative pathology
dc.subject laterality
dc.subject population-based
dc.subject TDP-43
dc.subject very old
dc.subject LEWY BODIES
dc.subject RARE CAUSE
dc.subject BRAIN
dc.subject AGE
dc.subject ASSOCIATION
dc.subject 3112 Neurosciences
dc.subject 3124 Neurology and psychiatry
dc.title Hippocampal Sclerosis in the Oldest Old : A Finnish Population-Based Study en
dc.type Article
dc.contributor.organization HUSLAB
dc.contributor.organization Medicum
dc.contributor.organization Department of Pathology
dc.contributor.organization Clinicum
dc.contributor.organization University of Helsinki
dc.contributor.organization Pentti Tienari / Principal Investigator
dc.contributor.organization Neurologian yksikkö
dc.contributor.organization Department of Neurosciences
dc.contributor.organization HUS Neurocenter
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.3233/JAD-171068
dc.relation.issn 1387-2877
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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