Testosterone is associated with insulin resistance index independently of adiposity in women with polycystic ovary syndrome

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http://hdl.handle.net/10138/235542

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Luotola , K , Piltonen , T T , Puurunen , J , Morin-Papunen , L C & Tapanainen , J S 2018 , ' Testosterone is associated with insulin resistance index independently of adiposity in women with polycystic ovary syndrome ' , Gynecological Endocrinology , vol. 34 , no. 1 , pp. 40-44 . https://doi.org/10.1080/09513590.2017.1342793

Title: Testosterone is associated with insulin resistance index independently of adiposity in women with polycystic ovary syndrome
Author: Luotola, Kari; Piltonen, Terhi T; Puurunen, Johanna; Morin-Papunen, Laure C; Tapanainen, Juha S
Contributor: University of Helsinki, Department of Medicine
University of Helsinki, Reproductive Disease Modeling
Date: 2018
Language: eng
Number of pages: 5
Belongs to series: Gynecological Endocrinology
ISSN: 0951-3590
URI: http://hdl.handle.net/10138/235542
Abstract: Objective: To study the associations between androgens, glucose homeostasis, inflammation and statin treatment in women with polycystic ovary syndrome (PCOS). Design and methods: Oral glucose tolerance tests, androgens, hs-CRP and interleukin-1 receptor antagonist (IL-1Ra) were analyzed at baseline and after 6months of atorvastatin (20 mg/d) or placebo treatment in 27 women with PCOS. Results: Testosterone associated with insulin resistance measured with ISIMatsuda independently of BMI, age and SHBG concentrations and the full model, including IL-1Ra, hs-CRP and HDL-C, also showed independency of BMI and waist circumference (p≤.042). Free androgen index (FAI) associated with ISIMatsuda independently of adiposity (p≤.025) but in the full model with waist circumference the association was insignificant. ISIMatsuda decreased with testosterone >1.2nmol/l compared with lower levels at baseline (p=.043) and at six months (p=.003). Accordingly, 30-minute insulin levels were increased with moderately elevated testosterone independently of adiposity (p≤.046). Increased fasting glucose and AUC insulin associated with statin treatment independently of adiposity and the associations attenuated after adjusting for testosterone.  Conclusions: Moderately elevated testosterone concentrations together with obesity-related inflammatory factors modify glucose homeostasis by increasing insulin resistance and early insulin secretion.
Subject: 3121 General medicine, internal medicine and other clinical medicine
3123 Gynaecology and paediatrics
Insulin secretion
insulin sensitivity
inflammation polycystic ovary syndrome
adiposity
androgens
IL-1 RECEPTOR ANTAGONIST
GLUCOSE-TOLERANCE
METABOLIC SYNDROME
PROSPECTIVE COHORT
DOUBLE-BLIND
FOLLOW-UP
SIMVASTATIN
SENSITIVITY
TRIAL
PCOS
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