Immunity against vaccine-preventable diseases in Finnish pediatric healthcare workers in 2015

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http://hdl.handle.net/10138/235564

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Koivisto , K , Puhakka , L , Lappalainen , M , Blomqvist , S , Saxen , H & Nieminen , T 2017 , ' Immunity against vaccine-preventable diseases in Finnish pediatric healthcare workers in 2015 ' , Vaccine , vol. 35 , no. 12 , pp. 1608-1614 . https://doi.org/10.1016/j.vaccine.2017.02.018

Title: Immunity against vaccine-preventable diseases in Finnish pediatric healthcare workers in 2015
Author: Koivisto, Karoliina; Puhakka, Laura; Lappalainen, Maija; Blomqvist, Soile; Saxen, Harri; Nieminen, Tea
Contributor: University of Helsinki, Clinicum
University of Helsinki, HUSLAB
University of Helsinki, Clinicum
University of Helsinki, Clinicum
Date: 2017-03-14
Language: eng
Number of pages: 7
Belongs to series: Vaccine
ISSN: 0264-410X
URI: http://hdl.handle.net/10138/235564
Abstract: Healthcare workers (HCWs) pose a risk to themselves and their patients if not protected against vaccine preventable diseases. Alarmingly, lacking immunity has been reported in several studies. We assessed the immunity against vaccine-preventable diseases in 157 pediatric HCWs in Helsinki Children's Hospital. The HCWs enrolled answered a questionnaire and gave a serum sample. Antibodies were measured with EIA against MMR-diseases, tetanus and diphtheria toxins, Hepatitis B (HBV), Hepatitis A (HAV), varicella zoster and pertussis toxin. Neutralizing antibodies against poliovirus 1, 2 and 3 were measured. All of the HCWs had antibodies against tetanus and 89.8% against diphtheria. All had measurable levels of polio antibodies to all three polioviruses. 41% had suboptimal levels of antibodies against at least one of the antigens tested: MMR-viruses, diphtheria, HBV or polio. Measles, mumps and rubella antibodies were detectable in 81.5%, 89.2% and 93%, respectively. Only one HCW had no varicella-antibodies. Hepatitis B surface antibodies (HBsAb) were detected in 89.8% of the nurses. 67.5% had HAV-antibodies. A poor correlation between detected antibody levels and reported vaccination history was noticed, indicating a need for a universal record system for registering the vaccines given to each individual. (C) 2017 Elsevier Ltd. All rights reserved.
Subject: Immunity
Vaccination
Vaccine-preventable diseases
Healthcare workers
PERTUSSIS BOOSTER VACCINATION
MUMPS-RUBELLA VACCINE
HEPATITIS-B
MEASLES
SUSCEPTIBILITY
ANTIBODIES
SEROPREVALENCE
IMMUNIZATION
PERSISTENCE
PREVALENCE
3111 Biomedicine
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