Estimation of main diversification time-points of hantaviruses using phylogenetic analyses of complete genomes

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Castel , G , Tordo , N & Plyusnin , A 2017 , ' Estimation of main diversification time-points of hantaviruses using phylogenetic analyses of complete genomes ' , Virus Research , vol. 233 , pp. 60-69 . https://doi.org/10.1016/j.virusres.2017.03.011

Title: Estimation of main diversification time-points of hantaviruses using phylogenetic analyses of complete genomes
Author: Castel, Guillaume; Tordo, Noel; Plyusnin, Alexander
Contributor: University of Helsinki, Medicum
Date: 2017-04-02
Language: eng
Number of pages: 10
Belongs to series: Virus Research
ISSN: 0168-1702
URI: http://hdl.handle.net/10138/235589
Abstract: Because of the great variability of their reservoir hosts, hantaviruses are excellent models to evaluate the dynamics of virus-host co-evolution. Intriguing questions remain about the timescale of the diversification events that influenced this evolution. In this paper we attempted to estimate the first ever timing of hantavirus diversification based on thirty five available complete genomes representing five major groups of hantaviruses and the assumption of co-speciation of hantaviruses with their respective mammal hosts. Phylogenetic analyses were used to estimate the main diversification points during hantavirus evolution in mammals while host diversification was mostly estimated from independent calibrators taken from fossil records. Our results support an earlier developed hypothesis of co-speciation of known hantaviruses with their respective mammal hosts and hence a common ancestor for all hantaviruses carried by placental mammals. (C) 2017 Elsevier B.V. All rights reserved.
Subject: Hantavirus
Diversification
Co-speciation
Phylogeny
MURINAE-ASSOCIATED HANTAVIRUSES
MOLECULAR EVOLUTION
SEQUENCE ALIGNMENT
PULMONARY SYNDROME
DIVERGENCE TIMES
GENUS HANTAVIRUS
TULA HANTAVIRUS
UNITED-STATES
VIRUS
DISCOVERY
3111 Biomedicine
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