Effects of frequent and long-term exercise on neuropsychiatric symptoms in patients with Alzheimer's disease - Secondary analyses of a randomized, controlled trial (FINALEX)

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Öhman , H , Savikko , N R N , Strandberg , T E , Kautiainen , H , Raivio , M M , Laakkonen , M L , Tilvis , R & Pitkala , K H 2017 , ' Effects of frequent and long-term exercise on neuropsychiatric symptoms in patients with Alzheimer's disease - Secondary analyses of a randomized, controlled trial (FINALEX) ' , European Geriatric Medicine , vol. 8 , no. 2 , pp. 153-157 . https://doi.org/10.1016/j.eurger.2017.01.004

Title: Effects of frequent and long-term exercise on neuropsychiatric symptoms in patients with Alzheimer's disease - Secondary analyses of a randomized, controlled trial (FINALEX)
Author: Öhman, Hannareeta; Savikko, N. R. N.; Strandberg, T. E.; Kautiainen, H.; Raivio, M. M.; Laakkonen, M. L.; Tilvis, R.; Pitkala, K. H.
Contributor organization: Clinicum
Department of General Practice and Primary Health Care
Department of Medicine
Timo Strandberg / Principal Investigator
Geriatrian yksikkö
HUS Internal Medicine and Rehabilitation
Teachers' Academy
Date: 2017-04
Language: eng
Number of pages: 5
Belongs to series: European Geriatric Medicine
ISSN: 1878-7649
DOI: https://doi.org/10.1016/j.eurger.2017.01.004
URI: http://hdl.handle.net/10138/235590
Abstract: Background: Neuropsychiatric symptoms (NPS) are common in Alzheimer's disease (AD) and are associated with admission to institutional care. Current guidelines recommend non-pharmacological interventions as the first-line treatment for NPS. However, high-quality randomized studies focused on NPS are scarce. The objective here was to examine whether a regular and long-term exercise programme either at home or as a group-based exercise at an adult day care centre has beneficial effects on AD patients' NPS or permanent institutionalizations. Design, setting, and participants: A randomized, controlled trial with 210 community-dwelling AD patients. Intervention: Two types of intervention comprising (1) group-based exercise in day care centres (GE) and (2) tailored home-based exercise (HE), both twice a week for 12 months, were compared with (3) a control group (CG) receiving usual community care. Measurements: NPS were measured with the Neuropsychiatric Inventory (NPI) at baseline and 6 months, and depression with the Cornell Scale for Depression in Dementia (CSDD) at baseline and 12 months. Data on institutionalizations were retrieved from central registers. Results: No significant differences between the groups were detected in NPI at 6 months or in CSDD at 12 months when analyses were adjusted for age, sex, baseline Clinical Dementia Rating, and Functional Independence Measure. There was no difference in admissions to permanent institutional care between the groups. Conclusions: Regular, long-term exercise intervention did not decrease NPS in patients with AD. (C) 2017 Elsevier Masson SAS and European Union Geriatric Medicine Society. All rights reserved.
Subject: Physical exercise
Neuropsychiatric symptoms
Depression
Alzheimer's disease
Randomized controlled trial
MILD COGNITIVE IMPAIRMENT
PSYCHOLOGICAL SYMPTOMS
NONPHARMACOLOGICAL THERAPIES
PHYSICAL-EXERCISE
CORNELL SCALE
OLDER-ADULTS
PART I
DEMENTIA
DEPRESSION
CONSORTIUM
3121 General medicine, internal medicine and other clinical medicine
Peer reviewed: Yes
Rights: unspecified
Usage restriction: openAccess
Self-archived version: publishedVersion


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