Effects of frequent and long-term exercise on neuropsychiatric symptoms in patients with Alzheimer's disease - Secondary analyses of a randomized, controlled trial (FINALEX)

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dc.contributor.author Öhman, Hannareeta
dc.contributor.author Savikko, N. R. N.
dc.contributor.author Strandberg, T. E.
dc.contributor.author Kautiainen, H.
dc.contributor.author Raivio, M. M.
dc.contributor.author Laakkonen, M. L.
dc.contributor.author Tilvis, R.
dc.contributor.author Pitkala, K. H.
dc.date.accessioned 2018-06-07T21:14:40Z
dc.date.available 2021-12-17T22:02:57Z
dc.date.issued 2017-04
dc.identifier.citation Öhman , H , Savikko , N R N , Strandberg , T E , Kautiainen , H , Raivio , M M , Laakkonen , M L , Tilvis , R & Pitkala , K H 2017 , ' Effects of frequent and long-term exercise on neuropsychiatric symptoms in patients with Alzheimer's disease - Secondary analyses of a randomized, controlled trial (FINALEX) ' , European Geriatric Medicine , vol. 8 , no. 2 , pp. 153-157 . https://doi.org/10.1016/j.eurger.2017.01.004
dc.identifier.other PURE: 85260068
dc.identifier.other PURE UUID: 61c1bebe-487f-4c0c-a9f5-4a4a30d3c07d
dc.identifier.other WOS: 000401440600013
dc.identifier.other Scopus: 85012005473
dc.identifier.other ORCID: /0000-0001-9659-6985/work/44141659
dc.identifier.other ORCID: /0000-0001-6299-925X/work/33744865
dc.identifier.uri http://hdl.handle.net/10138/235590
dc.description.abstract Background: Neuropsychiatric symptoms (NPS) are common in Alzheimer's disease (AD) and are associated with admission to institutional care. Current guidelines recommend non-pharmacological interventions as the first-line treatment for NPS. However, high-quality randomized studies focused on NPS are scarce. The objective here was to examine whether a regular and long-term exercise programme either at home or as a group-based exercise at an adult day care centre has beneficial effects on AD patients' NPS or permanent institutionalizations. Design, setting, and participants: A randomized, controlled trial with 210 community-dwelling AD patients. Intervention: Two types of intervention comprising (1) group-based exercise in day care centres (GE) and (2) tailored home-based exercise (HE), both twice a week for 12 months, were compared with (3) a control group (CG) receiving usual community care. Measurements: NPS were measured with the Neuropsychiatric Inventory (NPI) at baseline and 6 months, and depression with the Cornell Scale for Depression in Dementia (CSDD) at baseline and 12 months. Data on institutionalizations were retrieved from central registers. Results: No significant differences between the groups were detected in NPI at 6 months or in CSDD at 12 months when analyses were adjusted for age, sex, baseline Clinical Dementia Rating, and Functional Independence Measure. There was no difference in admissions to permanent institutional care between the groups. Conclusions: Regular, long-term exercise intervention did not decrease NPS in patients with AD. (C) 2017 Elsevier Masson SAS and European Union Geriatric Medicine Society. All rights reserved. en
dc.format.extent 5
dc.language.iso eng
dc.relation.ispartof European Geriatric Medicine
dc.rights unspecified
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject Physical exercise
dc.subject Neuropsychiatric symptoms
dc.subject Depression
dc.subject Alzheimer's disease
dc.subject Randomized controlled trial
dc.subject MILD COGNITIVE IMPAIRMENT
dc.subject PSYCHOLOGICAL SYMPTOMS
dc.subject NONPHARMACOLOGICAL THERAPIES
dc.subject PHYSICAL-EXERCISE
dc.subject CORNELL SCALE
dc.subject OLDER-ADULTS
dc.subject PART I
dc.subject DEMENTIA
dc.subject DEPRESSION
dc.subject CONSORTIUM
dc.subject 3121 General medicine, internal medicine and other clinical medicine
dc.title Effects of frequent and long-term exercise on neuropsychiatric symptoms in patients with Alzheimer's disease - Secondary analyses of a randomized, controlled trial (FINALEX) en
dc.type Article
dc.contributor.organization Clinicum
dc.contributor.organization Department of General Practice and Primary Health Care
dc.contributor.organization Department of Medicine
dc.contributor.organization Timo Strandberg / Principal Investigator
dc.contributor.organization Geriatrian yksikkö
dc.contributor.organization HUS Internal Medicine and Rehabilitation
dc.contributor.organization Teachers' Academy
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1016/j.eurger.2017.01.004
dc.relation.issn 1878-7649
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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