Peripheral DNA methylation, cognitive decline and brain aging : pilot findings from the Whitehall II imaging study

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Chouliaras , L , Pishva , E , Haapakoski , R , Zsoldos , E , Mahmood , A , Filippini , N , Burrage , J , Mill , J , Kivimäki , M , Lunnon , K & Ebmeier , K P 2018 , ' Peripheral DNA methylation, cognitive decline and brain aging : pilot findings from the Whitehall II imaging study ' , Epigenomics , vol. 10 , no. 5 , pp. 585-595 . https://doi.org/10.2217/epi-2017-0132

Title: Peripheral DNA methylation, cognitive decline and brain aging : pilot findings from the Whitehall II imaging study
Author: Chouliaras, Leonidas; Pishva, Ehsan; Haapakoski, Rita; Zsoldos, Eniko; Mahmood, Abda; Filippini, Nicola; Burrage, Joe; Mill, Jonathan; Kivimäki, Mika; Lunnon, Katie; Ebmeier, Klaus P.
Other contributor: University of Helsinki, Clinicum


Date: 2018-05
Language: eng
Number of pages: 11
Belongs to series: Epigenomics
ISSN: 1750-1911
DOI: https://doi.org/10.2217/epi-2017-0132
URI: http://hdl.handle.net/10138/235988
Abstract: Aim: The present study investigated the link between peripheral DNA methylation (DNAm), cognitive impairment and brain aging. Methods: We tested the association between blood genome-wide DNAm profiles using the Illumina 450K arrays, cognitive dysfunction and brain MRI measures in selected participants of the Whitehall II imaging sub-study. Results: Eight differentially methylated regions were associated with cognitive impairment. Accelerated aging based on the Hannum epigenetic clock was associated with mean diffusivity and global fractional anisotropy. We also identified modules of co-methylated loci associated with white matter hyperintensities. These co-methylation modules were enriched among pathways relevant to beta-amyloid processing and glutamatergic signaling. Conclusion: Our data support the notion that blood DNAm changes may have utility as a biomarker for cognitive dysfunction and brain aging.
Subject: brain aging
DNA methylation
epigenetic clock
MCI
mild cognitive impairment
MRI
peripheral biomarker
MESSENGER-RNA EXPRESSION
ALZHEIMERS-DISEASE
INTRON 1
BLOOD
DEMENTIA
TREM2
AGE
DYSREGULATION
HIPPOCAMPUS
ENRICHMENT
3111 Biomedicine
3112 Neurosciences
3124 Neurology and psychiatry
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