Peripheral DNA methylation, cognitive decline and brain aging : pilot findings from the Whitehall II imaging study

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dc.contributor.author Chouliaras, Leonidas
dc.contributor.author Pishva, Ehsan
dc.contributor.author Haapakoski, Rita
dc.contributor.author Zsoldos, Eniko
dc.contributor.author Mahmood, Abda
dc.contributor.author Filippini, Nicola
dc.contributor.author Burrage, Joe
dc.contributor.author Mill, Jonathan
dc.contributor.author Kivimäki, Mika
dc.contributor.author Lunnon, Katie
dc.contributor.author Ebmeier, Klaus P.
dc.date.accessioned 2018-06-12T09:12:01Z
dc.date.available 2018-06-12T09:12:01Z
dc.date.issued 2018-05
dc.identifier.citation Chouliaras , L , Pishva , E , Haapakoski , R , Zsoldos , E , Mahmood , A , Filippini , N , Burrage , J , Mill , J , Kivimäki , M , Lunnon , K & Ebmeier , K P 2018 , ' Peripheral DNA methylation, cognitive decline and brain aging : pilot findings from the Whitehall II imaging study ' , Epigenomics , vol. 10 , no. 5 , pp. 585-595 . https://doi.org/10.2217/epi-2017-0132
dc.identifier.other PURE: 107550294
dc.identifier.other PURE UUID: bece4c99-2156-402a-a1cc-edcfb1dde18b
dc.identifier.other WOS: 000432201400006
dc.identifier.other Scopus: 85047125932
dc.identifier.uri http://hdl.handle.net/10138/235988
dc.description.abstract Aim: The present study investigated the link between peripheral DNA methylation (DNAm), cognitive impairment and brain aging. Methods: We tested the association between blood genome-wide DNAm profiles using the Illumina 450K arrays, cognitive dysfunction and brain MRI measures in selected participants of the Whitehall II imaging sub-study. Results: Eight differentially methylated regions were associated with cognitive impairment. Accelerated aging based on the Hannum epigenetic clock was associated with mean diffusivity and global fractional anisotropy. We also identified modules of co-methylated loci associated with white matter hyperintensities. These co-methylation modules were enriched among pathways relevant to beta-amyloid processing and glutamatergic signaling. Conclusion: Our data support the notion that blood DNAm changes may have utility as a biomarker for cognitive dysfunction and brain aging. en
dc.format.extent 11
dc.language.iso eng
dc.relation.ispartof Epigenomics
dc.rights cc_by_nc_nd
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject brain aging
dc.subject DNA methylation
dc.subject epigenetic clock
dc.subject MCI
dc.subject mild cognitive impairment
dc.subject MRI
dc.subject peripheral biomarker
dc.subject MESSENGER-RNA EXPRESSION
dc.subject ALZHEIMERS-DISEASE
dc.subject INTRON 1
dc.subject BLOOD
dc.subject DEMENTIA
dc.subject TREM2
dc.subject AGE
dc.subject DYSREGULATION
dc.subject HIPPOCAMPUS
dc.subject ENRICHMENT
dc.subject 3111 Biomedicine
dc.subject 3112 Neurosciences
dc.subject 3124 Neurology and psychiatry
dc.title Peripheral DNA methylation, cognitive decline and brain aging : pilot findings from the Whitehall II imaging study en
dc.type Article
dc.contributor.organization Clinicum
dc.contributor.organization Department of Public Health
dc.contributor.organization University of Helsinki
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.2217/epi-2017-0132
dc.relation.issn 1750-1911
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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