Low galactosylation of IgG associates with higher risk for future diagnosis of rheumatoid arthritis during 10 years of follow-up

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Gudelj , I , Salo , P P , Trbojevic-Akmacic , I , Albers , M , Primorac , D , Perola , M & Lauc , G 2018 , ' Low galactosylation of IgG associates with higher risk for future diagnosis of rheumatoid arthritis during 10 years of follow-up ' , Biochimica et Biophysica Acta. Molecular Basis of Disease , vol. 1864 , no. 6 , pp. 2034-2039 . https://doi.org/10.1016/j.bbadis.2018.03.018

Title: Low galactosylation of IgG associates with higher risk for future diagnosis of rheumatoid arthritis during 10 years of follow-up
Author: Gudelj, Ivan; Salo, Perttu P.; Trbojevic-Akmacic, Irena; Albers, Malena; Primorac, Dragan; Perola, Markus; Lauc, Gordan
Contributor: University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Research Programs Unit
Date: 2018-06
Language: eng
Number of pages: 6
Belongs to series: Biochimica et Biophysica Acta. Molecular Basis of Disease
ISSN: 0925-4439
URI: http://hdl.handle.net/10138/235999
Abstract: Antibodies are known to have an important role in the development of rheumatoid arthritis (RA), one of the most prevalent chronic inflammatory diseases which primarily involves the joints. Most RA patients develop auto antibodies against immunoglobulin G (IgG) and changes in IgG glycosylation have been associated with RA. We undertook this study to determine whether altered IgG glycosylation precedes the disease diagnosis. We studied IgG glycosylation in RA in two prospective cohorts (N = 14,749) by measuring 28 IgG glycan traits in 179 subjects who developed RA within 10-years follow-up and 358 matched controls. Ultra-performance liquid chromatography method based on hydrophilic interactions (HILIC-UPLC) was used to analyse IgG glycans. Future RA diagnosis associated with traits related to lower galactosylation and sialylation of IgG when comparing the cases to the matched controls. In RA cases, these traits did not correlate with the time between being recruited to the study and being diagnosed with RA (median time 4.31 years). The difference in IgG glycosylation was relatively stable and present years before diagnosis. This indicates that long-acting factors affecting IgG glycome composition are among the underlying mechanisms of RA and that decreased galactosylation is a preexisting risk factor involved in the disease development.
Subject: Rheumatoid arthritis
Immunoglobulin G
N-glycans
Biomarker
Risk factor
SYSTEMIC-LUPUS-ERYTHEMATOSUS
IMMUNOGLOBULIN-G
DISEASE-ACTIVITY
CITRULLINATED PROTEINS
N-GLYCOSYLATION
AGALACTOSYL IGG
SERUM IGG
ANTIBODIES
PREGNANCY
RA
3111 Biomedicine
1182 Biochemistry, cell and molecular biology
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