Serotonin and neuroplasticity - Links between molecular, functional and structural pathophysiology in depression

Show simple item record

dc.contributor.author Kraus, Christoph
dc.contributor.author Castrén, Eero
dc.contributor.author Kasper, Siegfried
dc.contributor.author Lanzenberger, Rupert
dc.date.accessioned 2018-06-13T21:13:56Z
dc.date.available 2021-12-17T22:03:03Z
dc.date.issued 2017-06
dc.identifier.citation Kraus , C , Castrén , E , Kasper , S & Lanzenberger , R 2017 , ' Serotonin and neuroplasticity - Links between molecular, functional and structural pathophysiology in depression ' , Neuroscience & Biobehavioral Reviews , vol. 77 , pp. 317-326 . https://doi.org/10.1016/j.neubiorev.2017.03.007
dc.identifier.other PURE: 85516425
dc.identifier.other PURE UUID: 92f609d2-4ed0-43d0-bfbb-ebed4e61242a
dc.identifier.other WOS: 000401973800024
dc.identifier.other Scopus: 85018487838
dc.identifier.other ORCID: /0000-0002-1402-2791/work/33999298
dc.identifier.uri http://hdl.handle.net/10138/236227
dc.description.abstract Serotonin modulates neuroplasticity, especially during early life, and dysfunctions in both systems likewise contribute to pathophysiology of depression. Recent findings demonstrate that serotonin reuptake inhibitors trigger reactivation of juvenile-like neuroplasticity. How these findings translate to clinical antidepressant treatment in major depressive disorder remains unclear. With this review, we link preclinical with clinical work on serotonin and neuroplasticity to bring two pathophysiologic models in clinical depression closer together. Dysfunctional developmental plasticity impacts on later-life cognitive and emotional functions, changes of synaptic serotonin levels and receptor levels are coupled with altered synaptic plasticity and neurogenesis. Structural magnetic resonance imaging in patients reveals disease-state-specific reductions of gray matter, a marker of neuroplasticity, and reversibility upon selective serotonin reuptake inhibitor treatment. Translational evidence from magnetic resonance imaging in animals support that reduced densities and sizes of neurons and reduced hippocampal volumes in depressive patients could be attributable to changes of serotonergic neuroplasticity. Since ketamine, physical exercise or learning enhance neuroplasticity, combinatory paradigms with selective serotonin reuptake inhibitors could enhance clinical treatment of depression. (C) 2017 Elsevier Ltd. All rights reserved. en
dc.format.extent 10
dc.language.iso eng
dc.relation.ispartof Neuroscience & Biobehavioral Reviews
dc.rights unspecified
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject Neuroplasticity
dc.subject Serotonin
dc.subject Depression
dc.subject Neurogenesis
dc.subject Structural magnetic resonance imaging
dc.subject Voxel-based morphometry
dc.subject Brain-derived neurotrophic factor
dc.subject VOXEL-BASED MORPHOMETRY
dc.subject ADULT HIPPOCAMPAL NEUROGENESIS
dc.subject DORSOLATERAL PREFRONTAL CORTEX
dc.subject LONG-TERM DEPRESSION
dc.subject SYNAPTIC PLASTICITY
dc.subject MAJOR DEPRESSION
dc.subject DENTATE GYRUS
dc.subject NEUROTROPHIC FACTOR
dc.subject 5-HT1A RECEPTORS
dc.subject MOOD DISORDERS
dc.subject 3112 Neurosciences
dc.subject 3124 Neurology and psychiatry
dc.title Serotonin and neuroplasticity - Links between molecular, functional and structural pathophysiology in depression en
dc.type Review Article
dc.contributor.organization Neuroscience Center
dc.contributor.organization Eero Castren / Principal Investigator
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1016/j.neubiorev.2017.03.007
dc.relation.issn 0149-7634
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

Files in this item

Total number of downloads: Loading...

Files Size Format View
Serotonin_and_neuroplasticity.pdf 1.190Mb PDF View/Open

This item appears in the following Collection(s)

Show simple item record