Resection of colorectal liver metastases after second-line chemotherapy : is it worthwhile? A LiverMetSurvey analysis of 6415 patients

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dc.contributor.author Adam, Rene
dc.contributor.author Yi, Bin
dc.contributor.author Innominato, Pasquale F.
dc.contributor.author Barroso, Eduardo
dc.contributor.author Laurent, Christophe
dc.contributor.author Giuliante, Felice
dc.contributor.author Capussotti, Lorenzo
dc.contributor.author Lapointe, Real
dc.contributor.author Regimbeau, Jean-Marc
dc.contributor.author Lopez-Ben, Santiago
dc.contributor.author Isoniemi, Helena
dc.contributor.author Hubert, Catherine
dc.contributor.author Lin, Jen-Kou
dc.contributor.author Gruenberger, Thomas
dc.contributor.author Elias, Dominique
dc.contributor.author Skipenko, Oleg G.
dc.contributor.author Guglielmi, Alfredo
dc.contributor.author LiverMetSurvey Int Contributing
dc.date.accessioned 2018-06-13T21:13:56Z
dc.date.available 2021-12-17T22:02:49Z
dc.date.issued 2017-06
dc.identifier.citation Adam , R , Yi , B , Innominato , P F , Barroso , E , Laurent , C , Giuliante , F , Capussotti , L , Lapointe , R , Regimbeau , J-M , Lopez-Ben , S , Isoniemi , H , Hubert , C , Lin , J-K , Gruenberger , T , Elias , D , Skipenko , O G , Guglielmi , A & LiverMetSurvey Int Contributing 2017 , ' Resection of colorectal liver metastases after second-line chemotherapy : is it worthwhile? A LiverMetSurvey analysis of 6415 patients ' , European Journal of Cancer , vol. 78 , pp. 7-15 . https://doi.org/10.1016/j.ejca.2017.03.009
dc.identifier.other PURE: 85516549
dc.identifier.other PURE UUID: 9ee5575c-de34-4138-b135-0967dc54ef28
dc.identifier.other WOS: 000401930300002
dc.identifier.other Scopus: 85017235176
dc.identifier.uri http://hdl.handle.net/10138/236228
dc.description.abstract Purpose: Patient outcome after resection of colorectal liver metastases (CLM) following second-line preoperative chemotherapy (PCT) performed for insufficient response or toxicity of the first-line, is little known and has here been compared to the outcome following first-line. Patients and methods: From January 2005 to June 2013, 5624 and 791 consecutive patients of a prospective international cohort received 1 and 2 PCT lines before CLM resection (group 1 and 2, respectively). Survival and prognostic factors were analysed. Results: After a mean follow-up of 30.1 months, there was no difference in survival from CLM diagnosis (median, 3-, and 5-year overall survival [OS]: 58.6 months, 76% and 49% in group 2 versus 58.9 months, 71% and 49% in group 1, respectively, P = 0.32). After hepatectomy, disease-free survival (DFS) was however shorter in group 2: 17.2 months, 27% and 15% versus 19.4 months, 32% and 23%, respectively (P = 0.001). Among the initially unresectable patients of group 1 and 2, no statistical difference in OS or DFS was observed. Independent predictors of worse OS in group 2 were positive primary lymph nodes, extrahepatic disease, tumour progression on second line, R2 resection and number of hepatectomies/year Conclusion: CLM resection following second-line PCT, after oncosurgically favourable selection, could bring similar OS compared to what observed after first-line. For initially unresectable patients, OS or DFS is comparable between first-and second-line PCT. Surgery should not be denied after the failure of first-line chemotherapy. (C) 2017 Elsevier Ltd. All rights reserved. en
dc.format.extent 9
dc.language.iso eng
dc.relation.ispartof European Journal of Cancer
dc.rights unspecified
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject Colorectal cancer
dc.subject Liver metastasis
dc.subject Preoperative chemotherapy
dc.subject Second line
dc.subject Hepatectomy
dc.subject LONG-TERM SURVIVAL
dc.subject SYSTEMIC CHEMOTHERAPY
dc.subject PHASE-II
dc.subject CANCER
dc.subject OXALIPLATIN
dc.subject INFUSION
dc.subject TRIAL
dc.subject 5-FLUOROURACIL
dc.subject PROGRESSION
dc.subject LEUCOVORIN
dc.subject 3122 Cancers
dc.title Resection of colorectal liver metastases after second-line chemotherapy : is it worthwhile? A LiverMetSurvey analysis of 6415 patients en
dc.type Article
dc.contributor.organization Clinicum
dc.contributor.organization IV kirurgian klinikka
dc.contributor.organization Department of Surgery
dc.contributor.organization HUS Abdominal Center
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1016/j.ejca.2017.03.009
dc.relation.issn 0959-8049
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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