Detection of enteroviruses in stools precedes islet autoimmunity by several months : possible evidence for slowly operating mechanisms in virus-induced autoimmunity

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Honkanen , H , Oikarinen , S , Nurminen , N , Laitinen , O , Huhtala , H , Lehtonen , J , Ruokoranta , T M , Hankaniemi , M M , Lecouturier , V , Almond , J , Tauriainen , S , Simell , O , Ilonen , J , Veijola , R , Viskari , H , Knip , J M & Hyöty , H 2017 , ' Detection of enteroviruses in stools precedes islet autoimmunity by several months : possible evidence for slowly operating mechanisms in virus-induced autoimmunity ' , Diabetologia , vol. 60 , no. 3 , pp. 424-431 . https://doi.org/10.1007/s00125-016-4177-z

Title: Detection of enteroviruses in stools precedes islet autoimmunity by several months : possible evidence for slowly operating mechanisms in virus-induced autoimmunity
Author: Honkanen, Hanna; Oikarinen, Sami; Nurminen, Noora; Laitinen, Olli; Huhtala, Heini; Lehtonen, Jussi; Ruokoranta, Tanja Marjaana; Hankaniemi, Minna M.; Lecouturier, Valerie; Almond, Jeffrey; Tauriainen, Sisko; Simell, Olli; Ilonen, Jorma; Veijola, R; Viskari, Hanna; Knip, Jan Mikael; Hyöty, Heikki
Contributor: University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Research Programs Unit
Date: 2017-03
Language: eng
Number of pages: 8
Belongs to series: Diabetologia
ISSN: 0012-186X
URI: http://hdl.handle.net/10138/236407
Abstract: Aims/hypothesis This case-control study was nested in a prospective birth cohort to evaluate whether the presence of enteroviruses in stools was associated with the appearance of islet autoimmunity in the Type 1 Diabetes Prediction and Prevention study in Finland. Methods Altogether, 1673 longitudinal stool samples from 129 case children who turned positive for multiple islet autoantibodies and 3108 stool samples from 282 matched control children were screened for the presence of enterovirus RNA using RT-PCR. Viral genotype was detected by sequencing. Results Case children had more enterovirus infections than control children (0.8 vs 0.6 infections per child). Time-dependent analysis indicated that this excess of infections occurred more than 1 year before the first detection of islet autoantibodies (6.3 vs 2.1 infections per 10 follow-up years). No such difference was seen in infections occurring less than 1 year before islet autoantibody seroconversion or after seroconversion. The most frequent enterovirus types included coxsackievirus A4 (28% of genotyped viruses), coxsackievirus A2 (14%) and coxsackievirus A16 (11%). Conculusion/hypothesis The results suggest that enterovirus infections diagnosed by detecting viral RNA in stools are associated with the development of islet autoimmunity with a time lag of several months.
Subject: Enterovirus
Genotyping
RT-P
Stool samples
Type 1 diabetes
TYPE-1 DIABETES-MELLITUS
BETA-CELL AUTOIMMUNITY
DIFFERENT EUROPEAN POPULATIONS
MONTHLY FECAL SAMPLES
HIGH GENETIC RISK
COXSACKIE-B
PERSISTENT INFECTION
PANCREATIC-ISLETS
BLOOD-SAMPLES
YOUNG DAISY
3121 General medicine, internal medicine and other clinical medicine
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