Frequent and intensive physical activity reduces risk of cardiovascular events in type 1 diabetes

Show simple item record Tikkanen-Dolenc, Heidi Waden, Johan Forsblom, Carol Harjutsalo, Valma Thorn, Lena M. Saraheimo, Markku Elonen, Nina Rosengård-Bärlund, Milla Gordin, Daniel Tikkanen, Heikki O. Groop, Per-Henrik FinnDiane Study Grp 2018-06-16T21:20:58Z 2021-12-17T22:02:14Z 2017-03
dc.identifier.citation Tikkanen-Dolenc , H , Waden , J , Forsblom , C , Harjutsalo , V , Thorn , L M , Saraheimo , M , Elonen , N , Rosengård-Bärlund , M , Gordin , D , Tikkanen , H O , Groop , P-H & FinnDiane Study Grp 2017 , ' Frequent and intensive physical activity reduces risk of cardiovascular events in type 1 diabetes ' , Diabetologia , vol. 60 , no. 3 , pp. 574-580 .
dc.identifier.other PURE: 85603394
dc.identifier.other PURE UUID: 7e9b9105-c3f2-442a-858d-19bb1529b483
dc.identifier.other WOS: 000394462100022
dc.identifier.other Scopus: 85007154339
dc.identifier.other ORCID: /0000-0003-3999-0390/work/40217143
dc.identifier.other ORCID: /0000-0003-1494-8292/work/40502843
dc.description.abstract Aims/hypothesis Cardiovascular disease (CVD) is the most common cause of premature death and disability among patients with type 1 diabetes. Diabetic nephropathy accounts for the increased cardiovascular morbidity and mortality of these patients. We recently showed that the intensity of exercise predicts the incidence and progression of diabetic nephropathy in patients with type 1 diabetes. Little is known about the relationship between physical activity and CVD. Therefore, we studied how physical activity affects the risk of CVD events in patients with type 1 diabetes. Methods A 10 year follow-up study including 2180 type 1 diabetes patients from the nationwide multicentre Finnish Diabetic Nephropathy Study (FinnDiane). Leisure time physical activity (LTPA) was assessed by a previously validated self-report questionnaire. A CVD event was defined as a verified myocardial infarction, coronary procedure or stroke. Patients were analysed separately for the risk of developing a first ever CVD event and for the risk of a recurrent CVD event following a baseline event. Results A total of 206 patients had an incident CVD event during follow-up. A higher total LTPA and higher intensity, frequency and duration of activity were associated with a lower risk of incident CVD events. The observed association between exercise frequency and incident CVD remained significant when adjusted for classic risk factors. Exercise intensity also had a borderline effect on the recurrence-free time in patients with a major CVD event at baseline. Conclusion/interprelation This study suggests that exercise, particularly high frequency and high intensity exercise, may reduce the risk of CVD events in patients with type 1 diabetes. en
dc.format.extent 7
dc.language.iso eng
dc.relation.ispartof Diabetologia
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject DISEASE
dc.subject NEPHROPATHY
dc.subject FINNDIANE
dc.subject MELLITUS
dc.subject HEART
dc.subject ASSOCIATION
dc.subject EXERCISE
dc.subject 3121 General medicine, internal medicine and other clinical medicine
dc.title Frequent and intensive physical activity reduces risk of cardiovascular events in type 1 diabetes en
dc.type Article
dc.contributor.organization HUS Abdominal Center
dc.contributor.organization Nefrologian yksikkö
dc.contributor.organization University of Helsinki
dc.contributor.organization Research Programs Unit
dc.contributor.organization Diabetes and Obesity Research Program
dc.contributor.organization Clinicum
dc.contributor.organization Department of Medicine
dc.contributor.organization Department of Diagnostics and Therapeutics
dc.contributor.organization Per Henrik Groop / Principal Investigator
dc.description.reviewstatus Peer reviewed
dc.relation.issn 0012-186X
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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