Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function

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Davies , G , Lam , M , Harris , S E , Trampush , J W , Luciano , M , Hill , W D , Hagenaars , S P , Ritchie , S J , Marioni , R E , Fawns-Ritchie , C , Liewald , D C M , Okely , J A , Ahola-Olli , A V , Barnes , C L K , Bertram , L , Bis , J C , Burdick , K E , Christoforou , A , DeRosse , P , Djurovic , S , Espeseth , T , Giakoumaki , S , Giddaluru , S , Gustavson , D E , Hayward , C , Hofer , E , Ikram , M A , Karlsson , R , Knowles , E , Lahti , J , Leber , M , Li , S , Mather , K A , Melle , I , Morris , D , Oldmeadow , C , Palviainen , T , Payton , A , Pazoki , R , Petrovic , K , Reynolds , C A , Sargurupremraj , M , Scholz , M , Eriksson , J G , Loukola , A , Kaprio , J , Widen , E , Vuoksimaa , E , Palotie , A , Weir , D R , Räikkönen , K & Lill , C M 2018 , ' Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function ' , Nature Communications , vol. 9 , 2098 .

Title: Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function
Author: Davies, Gail; Lam, Max; Harris, Sarah E.; Trampush, Joey W.; Luciano, Michelle; Hill, W. David; Hagenaars, Saskia P.; Ritchie, Stuart J.; Marioni, Riccardo E.; Fawns-Ritchie, Chloe; Liewald, David C. M.; Okely, Judith A.; Ahola-Olli, Ari V.; Barnes, Catriona L. K.; Bertram, Lars; Bis, Joshua C.; Burdick, Katherine E.; Christoforou, Andrea; DeRosse, Pamela; Djurovic, Srdjan; Espeseth, Thomas; Giakoumaki, Stella; Giddaluru, Sudheer; Gustavson, Daniel E.; Hayward, Caroline; Hofer, Edith; Ikram, M. Arfan; Karlsson, Robert; Knowles, Emma; Lahti, Jari; Leber, Markus; Li, Shuo; Mather, Karen A.; Melle, Ingrid; Morris, Derek; Oldmeadow, Christopher; Palviainen, Teemu; Payton, Antony; Pazoki, Raha; Petrovic, Katja; Reynolds, Chandra A.; Sargurupremraj, Muralidharan; Scholz, Markus; Eriksson, Johan G.; Loukola, Anu; Kaprio, Jaakko; Widen, Elisabeth; Vuoksimaa, Eero; Palotie, Aarno; Weir, David R.; Räikkönen, Katri; Lill, Christina M.
Contributor organization: Medicum
Helsinki Collegium for Advanced Studies
Department of Psychology and Logopedics
Institute for Molecular Medicine Finland
University of Helsinki
Johan Eriksson / Principal Investigator
Department of General Practice and Primary Health Care
Diabetes and Obesity Research Program
Research Programs Unit
Department of Public Health
Elisabeth Ingrid Maria Widen / Principal Investigator
Centre of Excellence in Complex Disease Genetics
Aarno Palotie / Principal Investigator
Department of Medical and Clinical Genetics
Developmental Psychology Research Group
Genomics of Neurological and Neuropsychiatric Disorders
Genetic Epidemiology
Genomic Discoveries and Clinical Translation
Date: 2018-05-29
Language: eng
Number of pages: 16
Belongs to series: Nature Communications
ISSN: 2041-1723
Abstract: General cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank (total N = 300,486; age 16-102) and find 148 genome-wide significant independent loci (P <5 x 10(-8)) associated with general cognitive function. Within the novel genetic loci are variants associated with neurodegenerative and neurodevelopmental disorders, physical and psychiatric illnesses, and brain structure. Gene-based analyses find 709 genes associated with general cognitive function. Expression levels across the cortex are associated with general cognitive function. Using polygenic scores, up to 4.3% of variance in general cognitive function is predicted in independent samples. We detect significant genetic overlap between general cognitive function, reaction time, and many health variables including eyesight, hypertension, and longevity. In conclusion we identify novel genetic loci and pathways contributing to the heritability of general cognitive function.
Description: Correction Volume: 10, Article Number: 2068 DOI: 10.1038/s41467-019-10160-w WOS:000466339700001
515 Psychology
3111 Biomedicine
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion

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