Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function

Davies, Gail; Lam, Max; Harris, Sarah E.; Trampush, Joey W.; Luciano, Michelle; Hill, W. David; Hagenaars, Saskia P.; Ritchie, Stuart J.; Marioni, Riccardo E.; Fawns-Ritchie, Chloe; Liewald, David C. M.; Okely, Judith A.; Ahola-Olli, Ari V.; Barnes, Catriona L. K.; Bertram, Lars; Bis, Joshua C.; Burdick, Katherine E.; Christoforou, Andrea; DeRosse, Pamela; Djurovic, Srdjan; Espeseth, Thomas; Giakoumaki, Stella; Giddaluru, Sudheer; Gustavson, Daniel E.; Hayward, Caroline; Hofer, Edith; Ikram, M. Arfan; Karlsson, Robert; Knowles, Emma; Lahti, Jari; Leber, Markus; Li, Shuo; Mather, Karen A.; Melle, Ingrid; Morris, Derek; Oldmeadow, Christopher; Palviainen, Teemu; Payton, Antony; Pazoki, Raha; Petrovic, Katja; Reynolds, Chandra A.; Sargurupremraj, Muralidharan; Scholz, Markus; Eriksson, Johan G.; Loukola, Anu; Kaprio, Jaakko; Widen, Elisabeth; Vuoksimaa, Eero; Palotie, Aarno; Weir, David R.; Räikkönen, Katri; Lill, Christina M.

Helda

Helsingin yliopisto

Helsingfors universitet

University of Helsinki

Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function

Show full item record

Download

Permalink

http://hdl.handle.net/10138/236439

https://doi.org/10.1038/s41467-018-04362-x

Citation

Davies , G , Lam , M , Harris , S E , Trampush , J W , Luciano , M , Hill , W D , Hagenaars , S P , Ritchie , S J , Marioni , R E , Fawns-Ritchie , C , Liewald , D C M , Okely , J A , Ahola-Olli , A V , Barnes , C L K , Bertram , L , Bis , J C , Burdick , K E , Christoforou , A , DeRosse , P , Djurovic , S , Espeseth , T , Giakoumaki , S , Giddaluru , S , Gustavson , D E , Hayward , C , Hofer , E , Ikram , M A , Karlsson , R , Knowles , E , Lahti , J , Leber , M , Li , S , Mather , K A , Melle , I , Morris , D , Oldmeadow , C , Palviainen , T , Payton , A , Pazoki , R , Petrovic , K , Reynolds , C A , Sargurupremraj , M , Scholz , M , Eriksson , J G , Loukola , A , Kaprio , J , Widen , E , Vuoksimaa , E , Palotie , A , Weir , D R , Räikkönen , K & Lill , C M 2018 , ' Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function ' , Nature Communications , vol. 9 , 2098 . https://doi.org/10.1038/s41467-018-04362-x

Title:	Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function
Author:	Davies, Gail; Lam, Max; Harris, Sarah E.; Trampush, Joey W.; Luciano, Michelle; Hill, W. David; Hagenaars, Saskia P.; Ritchie, Stuart J.; Marioni, Riccardo E.; Fawns-Ritchie, Chloe; Liewald, David C. M.; Okely, Judith A.; Ahola-Olli, Ari V.; Barnes, Catriona L. K.; Bertram, Lars; Bis, Joshua C.; Burdick, Katherine E.; Christoforou, Andrea; DeRosse, Pamela; Djurovic, Srdjan; Espeseth, Thomas; Giakoumaki, Stella; Giddaluru, Sudheer; Gustavson, Daniel E.; Hayward, Caroline; Hofer, Edith; Ikram, M. Arfan; Karlsson, Robert; Knowles, Emma; Lahti, Jari; Leber, Markus; Li, Shuo; Mather, Karen A.; Melle, Ingrid; Morris, Derek; Oldmeadow, Christopher; Palviainen, Teemu; Payton, Antony; Pazoki, Raha; Petrovic, Katja; Reynolds, Chandra A.; Sargurupremraj, Muralidharan; Scholz, Markus; Eriksson, Johan G.; Loukola, Anu; Kaprio, Jaakko; Widen, Elisabeth; Vuoksimaa, Eero; Palotie, Aarno; Weir, David R.; Räikkönen, Katri; Lill, Christina M.
Contributor organization:	Medicum Helsinki Collegium for Advanced Studies Department of Psychology and Logopedics Institute for Molecular Medicine Finland University of Helsinki Clinicum Johan Eriksson / Principal Investigator Department of General Practice and Primary Health Care Diabetes and Obesity Research Program Research Programs Unit Department of Public Health Elisabeth Ingrid Maria Widen / Principal Investigator Centre of Excellence in Complex Disease Genetics Aarno Palotie / Principal Investigator Department of Medical and Clinical Genetics Developmental Psychology Research Group Genomics of Neurological and Neuropsychiatric Disorders Genetic Epidemiology Genomic Discoveries and Clinical Translation
Date:	2018-05-29
Language:	eng
Number of pages:	16
Belongs to series:	Nature Communications
ISSN:	2041-1723
DOI:	https://doi.org/10.1038/s41467-018-04362-x
URI:	http://hdl.handle.net/10138/236439
Abstract:	General cognitive function is a prominent and relatively stable human trait that is associated with many important life outcomes. We combine cognitive and genetic data from the CHARGE and COGENT consortia, and UK Biobank (total N = 300,486; age 16-102) and find 148 genome-wide significant independent loci (P <5 x 10(-8)) associated with general cognitive function. Within the novel genetic loci are variants associated with neurodegenerative and neurodevelopmental disorders, physical and psychiatric illnesses, and brain structure. Gene-based analyses find 709 genes associated with general cognitive function. Expression levels across the cortex are associated with general cognitive function. Using polygenic scores, up to 4.3% of variance in general cognitive function is predicted in independent samples. We detect significant genetic overlap between general cognitive function, reaction time, and many health variables including eyesight, hypertension, and longevity. In conclusion we identify novel genetic loci and pathways contributing to the heritability of general cognitive function.
Description:	Correction Volume: 10, Article Number: 2068 DOI: 10.1038/s41467-019-10160-w WOS:000466339700001
Subject:	GENOME-WIDE ASSOCIATION HUMAN INTELLIGENCE REACTION-TIME EDUCATIONAL-ATTAINMENT PARKINSONS-DISEASE PROCESSING SPEED COMMON VARIANTS HUMAN LONGEVITY OLD-AGE METAANALYSIS 515 Psychology 3111 Biomedicine
Peer reviewed:	Yes
Rights:	cc_by
Usage restriction:	openAccess
Self-archived version:	publishedVersion

Files in this item

Total number of downloads: Loading...

Files	Size	Format	View
s41467_018_04362_x.pdf	3.145Mb	PDF	View/Open
s41467_019_10160_w.pdf	1.495Mb	PDF	View/Open

This item appears in the following Collection(s)

Articles from TUHAT system [53185]

Show full item record