Potential Diarrheal Pathogens Common Also in Healthy Children in Angola

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dc.contributor.author Pelkonen, Tuula
dc.contributor.author dos Santos, Mauro Dias
dc.contributor.author Roine, Irmeli
dc.contributor.author dos Anjos, Elisabete
dc.contributor.author Freitas, Cesar
dc.contributor.author Peltola, Heikki
dc.contributor.author Laakso, Sanna
dc.contributor.author Kirveskari, Juha
dc.date.accessioned 2018-06-18T12:22:37Z
dc.date.available 2018-06-18T12:22:37Z
dc.date.issued 2018-05
dc.identifier.citation Pelkonen , T , dos Santos , M D , Roine , I , dos Anjos , E , Freitas , C , Peltola , H , Laakso , S & Kirveskari , J 2018 , ' Potential Diarrheal Pathogens Common Also in Healthy Children in Angola ' , Pediatric Infectious Disease Journal , vol. 37 , no. 5 , pp. 424-428 . https://doi.org/10.1097/INF.0000000000001781
dc.identifier.other PURE: 107837260
dc.identifier.other PURE UUID: b22faa0d-b4f0-46c1-b0fb-763281d61162
dc.identifier.other WOS: 000433233100017
dc.identifier.other Scopus: 85061138464
dc.identifier.uri http://hdl.handle.net/10138/236441
dc.description.abstract Background: Globally, diarrhea kills almost 1500 children daily. In diagnostics, molecular methods are replacing traditional assays. We aimed to investigate enteropathogens in children with and without diarrhea in Luanda, the capital of Angola. Methods: One hundred and ninety-four stool samples from 98 children with acute diarrhea and 96 children without diarrhea were investigated for 17 enteropathogens with multiplex real-time polymerase chain reaction. Results: The median age of children was 10.5 months. Enteropathogens, bacteria, viruses and parasites were detected in 91%, 78%, 50% and 25%, respectively. A positive finding was significantly (P = 0.003) more common in diarrhea when testing for all pathogens combined, for bacteria alone and for viruses alone. More than one pathogen was found more frequently in diarrhea than in non-diarrhea stool samples, in 87% and in 59% (P <0.0001), respectively. The median number (interquartile range) of pathogens detected was 3 (2) versus 1.5 (2; P <0.0001), respectively. When age was taken into account, diarrhea was found to be associated with enterotoxigenic and enteroaggregative Escherichia coli, Shigella, Campylobacter, rotavirus, sapovirus and Cryptosporidium. Conclusions: Multiplex polymerase chain reaction detected enteropathogens in almost all stool samples of children in Luanda, albeit this occurred more often in diarrhea. Children with diarrhea showed more mixed infections than children without diarrhea. en
dc.format.extent 5
dc.language.iso eng
dc.relation.ispartof Pediatric Infectious Disease Journal
dc.rights cc_by_nc_nd
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject diarrhea
dc.subject children
dc.subject developing countries
dc.subject etiology
dc.subject multiplex real-time PCR
dc.subject ETIOLOGY
dc.subject MULTICENTER
dc.subject YOUNGER
dc.subject DISEASE
dc.subject BURDEN
dc.subject STOOLS
dc.subject GEMS
dc.subject AGE
dc.subject 3123 Gynaecology and paediatrics
dc.title Potential Diarrheal Pathogens Common Also in Healthy Children in Angola en
dc.type Article
dc.contributor.organization Children's Hospital
dc.contributor.organization University of Helsinki
dc.contributor.organization Clinicum
dc.contributor.organization Lastentautien yksikkö
dc.contributor.organization HUS Children and Adolescents
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1097/INF.0000000000001781
dc.relation.issn 0891-3668
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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