Abnormal lung function at preschool age – asthma in adolescence?

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Lajunen , K , Kalliola , S , Kotaniemi-Syrjänen , A , Sarna , S , Malmberg , L P , Pelkonen , A S & Mäkelä , M J 2018 , ' Abnormal lung function at preschool age – asthma in adolescence? ' , Annals of Allergy, Asthma, & Immunology , vol. 120 , no. 5 , pp. 520-526 . https://doi.org/10.1016/j.anai.2018.03.002

Title: Abnormal lung function at preschool age – asthma in adolescence?
Author: Lajunen, Katariina; Kalliola, Satu; Kotaniemi-Syrjänen, Anne; Sarna, Seppo; Malmberg, L. Pekka; Pelkonen, Anna S.; Mäkelä, Mika J.
Contributor organization: Department of Dermatology, Allergology and Venereology
HUS Inflammation Center
Children's Hospital
HUS Children and Adolescents
Seppo Sarna / Principal Investigator
Date: 2018-05
Language: eng
Number of pages: 7
Belongs to series: Annals of Allergy, Asthma, & Immunology
ISSN: 1081-1206
DOI: https://doi.org/10.1016/j.anai.2018.03.002
URI: http://hdl.handle.net/10138/236493
Abstract: Background: Asthma often begins early in childhood. However, the risk for persistence is challenging to evaluate. Objective: This longitudinal study relates lung function assessed with impulse oscillometry (IOS) in preschool children to asthma in adolescence. Methods: Lung function was measured with IOS in 255 children with asthma-like symptoms aged 4-7 years. Baseline measurements were followed by exercise challenge and bronchodilation tests. At age 12-16 years, 121 children participated in the follow-up visit, when lung function was assessed with spirometry, followed by a bronchodilation test. Asthma symptoms and medication were recorded by a questionnaire and atopy defined by skin prick tests. Results: Abnormal baseline values in preschool IOS were significantly associated with low lung function, the need for asthma medication, and asthma symptoms in adolescence. Preschool abnormal R5 at baseline (z-score >= 1.645 SD) showed 9.2 odds ratio (95% CI 2.7; 31.7) for abnormal FEV1/FVC, use of asthma medication in adolescence, and 9.9 odds ratio (95% CI 2.9; 34.4) for asthma symptoms. Positive exercise challenge and modified asthma-predictive index at preschool age predicted asthma symptoms and the need for asthma medication, but not abnormal lung function at teenage. Conclusion: Abnormal preschool IOS is associated with asthma and poor lung function in adolescence and might be utilised for identification of asthma persistence. (c) 2018 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc.
Subject: Adolescence
childhood asthma
exercise challenge
impulse oscillometry
longitudinal study
lung function testing
3123 Gynaecology and paediatrics
Peer reviewed: Yes
Rights: cc_by_nc_nd
Usage restriction: openAccess
Self-archived version: acceptedVersion

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