Genetic predisposition to obesity, restrained eating and changes in body weight: a population-based prospective study

Show simple item record Konttinen, H. Llewellyn, C. Silventoinen, K. Joensuu, A. Männistö, S. Salomaa, V. Jousilahti, P. Kaprio, J. Perola, M. Haukkala, A. 2018-06-19T11:04:01Z 2021-12-17T03:45:41Z 2018-04
dc.identifier.citation Konttinen , H , Llewellyn , C , Silventoinen , K , Joensuu , A , Männistö , S , Salomaa , V , Jousilahti , P , Kaprio , J , Perola , M & Haukkala , A 2018 , ' Genetic predisposition to obesity, restrained eating and changes in body weight: a population-based prospective study ' , International Journal of Obesity , vol. 42 , no. 4 , pp. 858-865 .
dc.identifier.other PURE: 97980037
dc.identifier.other PURE UUID: 6e33c169-2dc1-4a61-95a5-b7f51df76c24
dc.identifier.other Bibtex: urn:be14d839cd64555ece0019f6f63fcc50
dc.identifier.other WOS: 000432681200034
dc.identifier.other Scopus: 85047248507
dc.identifier.other ORCID: /0000-0002-6001-4418/work/45821415
dc.identifier.other ORCID: /0000-0001-8567-1548/work/45821428
dc.identifier.other ORCID: /0000-0003-1759-3079/work/55061998
dc.description.abstract OBJECTIVES: There is no consensus on whether cognitive control over food intake (that is, restrained eating) is helpful, merely ineffective or actually harmful in weight management. We examined the interplay between genetic risk of obesity, restrained eating and changes in body weight and size. METHODS: Participants were Finnish aged 25-74 years who attended the Dietary. Lifestyle and Genetic determinants of Obesity and Metabolic syndrome study at baseline in 2007 and follow-up in 2014. At baseline (n=5024), height, weight and waist circumference (WC) were measured in a health examination and participants self-reported their weight at age 20 years. At follow-up (n=3735), height, weight and WC were based on measured or self-reported information. We calculated 7-year change in body mass index (BMI) and WC and annual weight change from age 20 years to baseline. Three-Factor Eating Questionnaire-R18 was used to assess restrained eating. Genetic risk of obesity was assessed by calculating a polygenic risk score of 97 known BMI-related loci. RESULTS: Cross-lagged autoregressive models indicated that baseline restrained eating was unrelated to 7-year change in BMI (beta=0.00; 95% confidence interval (CI) =-0.01, 0.02). Instead, higher baseline BMI predicted greater 7-year increases in restrained eating (beta = 0.08; 95% CI =0.05, 0.11). Similar results were obtained with WC. Polygenic risk score correlated positively with restrained eating and obesity indicators in both study phases, but it did not predict 7-year change in BMI or WC. However, individuals with higher genetic risk of obesity tended to gain more weight from age 20 years to baseline, and this association was more pronounced in unrestrained eaters than in restrained eaters (P=0.038 for interaction). CONCLUSIONS: Our results suggest that restrained eating is a marker for previous weight gain rather than a factor that leads to future weight gain in middle-aged adults. Genetic influences on weight gain from early to middle adulthood may vary according to restrained eating, but this finding needs to be replicated in future studies. en
dc.format.extent 8
dc.language.iso eng
dc.relation.ispartof International Journal of Obesity
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject 3121 General medicine, internal medicine and other clinical medicine
dc.subject 5144 Social psychology
dc.subject MASS INDEX
dc.subject TWIN COHORTS
dc.subject ADULT TWINS
dc.subject BMI
dc.subject RISK
dc.subject WOMEN
dc.subject GAIN
dc.title Genetic predisposition to obesity, restrained eating and changes in body weight: a population-based prospective study en
dc.type Article
dc.contributor.organization Department of Food and Nutrition
dc.contributor.organization Social Psychology
dc.contributor.organization Center for Population, Health and Society
dc.contributor.organization Sociology
dc.contributor.organization Department of Social Research (2010-2017)
dc.contributor.organization Quantitative Genetics
dc.contributor.organization Institute for Molecular Medicine Finland
dc.contributor.organization Department of Public Health
dc.contributor.organization Clinicum
dc.contributor.organization University of Helsinki
dc.contributor.organization Research Programs Unit
dc.contributor.organization Diabetes and Obesity Research Program
dc.contributor.organization Research group of Ari Haukkala
dc.contributor.organization Population Research Unit (PRU)
dc.contributor.organization Genetic Epidemiology
dc.description.reviewstatus Peer reviewed
dc.relation.issn 0307-0565
dc.rights.accesslevel openAccess
dc.type.version acceptedVersion

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