Association of circulating metabolites with healthy diet and risk of cardiovascular disease : analysis of two cohort studies

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Akbaraly , T , Wurtz , P , Singh-Manoux , A , Shipley , M J , Haapakoski , R , Lehto , M , Desrumaux , C , Kähönen , M , Lehtimäki , T , Mikkilä , V , Hingorani , A , Humphries , S E , Kangas , A J , Soininen , P , Raitakari , O , Ala-Korpela , M & Kivimäki , M 2018 , ' Association of circulating metabolites with healthy diet and risk of cardiovascular disease : analysis of two cohort studies ' , Scientific Reports , vol. 8 , 8620 . https://doi.org/10.1038/s41598-018-26441-1

Titel: Association of circulating metabolites with healthy diet and risk of cardiovascular disease : analysis of two cohort studies
Författare: Akbaraly, Tasnime; Wurtz, Peter; Singh-Manoux, Archana; Shipley, Martin J.; Haapakoski, Rita; Lehto, Maili; Desrumaux, Catherine; Kähönen, Mika; Lehtimäki, Terho; Mikkilä, Vera; Hingorani, Aroon; Humphries, Steve E.; Kangas, Antti J.; Soininen, Pasi; Raitakari, Olli; Ala-Korpela, Mika; Kivimäki, Mika
Upphovmannens organisation: Clinicum
Department of Public Health
University of Helsinki
Datum: 2018-06-05
Språk: eng
Sidantal: 14
Tillhör serie: Scientific Reports
ISSN: 2045-2322
DOI: https://doi.org/10.1038/s41598-018-26441-1
Permanenta länken (URI): http://hdl.handle.net/10138/236582
Abstrakt: Diet may modify metabolomic profiles towards higher or lower cardiovascular disease (CVD) risk. We aimed to identify metabolite profiles associated with high adherence to dietary recommendations-the Alternative Healthy Eating Index (AHEI) - and the extent to which metabolites associated with AHEI also predict incident CVD. Relations between AHEI score and 80 circulating lipids and metabolites, quantified by nuclear magnetic resonance metabolomics, were examined using linear regression models in the Whitehall II study (n = 4824, 55.9 +/- 6.1 years, 28.0% women) and were replicated in the Cardiovascular Risk in Young Finns Study (n = 1716, 37.7 +/- 5.0 years, 56.3% women). We used Cox models to study associations between metabolites and incident CVD over the 15.8-year follow-up in the Whitehall II study. After adjustment for confounders, higher AHEI score (indicating healthier diet) was associated with higher degree of unsaturation of fatty acids (FA) and higher ratios of polyunsaturated FA, omega-3 and docosahexaenoic acid relative to total FA in both Whitehall II and Young Finns studies. A concordance of associations of metabolites with higher AHEI score and lower CVD risk was observed in Whitehall II. Adherence to healthy diet seems to be associated with specific FA that reduce risk of CVD.
Subject: NUCLEAR-MAGNETIC-RESONANCE
CORONARY-HEART-DISEASE
WHITEHALL II COHORT
FATTY-ACIDS
PARTICLE-SIZE
EATING INDEX
YOUNG FINNS
METABOLOMICS
WOMEN
MEN
3121 General medicine, internal medicine and other clinical medicine
3142 Public health care science, environmental and occupational health
Referentgranskad: Ja
Licens: cc_by
Användningsbegränsning: openAccess
Parallelpublicerad version: publishedVersion


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