Association of circulating metabolites with healthy diet and risk of cardiovascular disease : analysis of two cohort studies

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dc.contributor.author Akbaraly, Tasnime
dc.contributor.author Wurtz, Peter
dc.contributor.author Singh-Manoux, Archana
dc.contributor.author Shipley, Martin J.
dc.contributor.author Haapakoski, Rita
dc.contributor.author Lehto, Maili
dc.contributor.author Desrumaux, Catherine
dc.contributor.author Kähönen, Mika
dc.contributor.author Lehtimäki, Terho
dc.contributor.author Mikkilä, Vera
dc.contributor.author Hingorani, Aroon
dc.contributor.author Humphries, Steve E.
dc.contributor.author Kangas, Antti J.
dc.contributor.author Soininen, Pasi
dc.contributor.author Raitakari, Olli
dc.contributor.author Ala-Korpela, Mika
dc.contributor.author Kivimäki, Mika
dc.date.accessioned 2018-06-21T08:26:01Z
dc.date.available 2018-06-21T08:26:01Z
dc.date.issued 2018-06-05
dc.identifier.citation Akbaraly , T , Wurtz , P , Singh-Manoux , A , Shipley , M J , Haapakoski , R , Lehto , M , Desrumaux , C , Kähönen , M , Lehtimäki , T , Mikkilä , V , Hingorani , A , Humphries , S E , Kangas , A J , Soininen , P , Raitakari , O , Ala-Korpela , M & Kivimäki , M 2018 , ' Association of circulating metabolites with healthy diet and risk of cardiovascular disease : analysis of two cohort studies ' , Scientific Reports , vol. 8 , 8620 . https://doi.org/10.1038/s41598-018-26441-1
dc.identifier.other PURE: 107996929
dc.identifier.other PURE UUID: d74c01fd-8835-449a-98ea-300726ca9722
dc.identifier.other WOS: 000434122600045
dc.identifier.other Scopus: 85048067224
dc.identifier.uri http://hdl.handle.net/10138/236582
dc.description.abstract Diet may modify metabolomic profiles towards higher or lower cardiovascular disease (CVD) risk. We aimed to identify metabolite profiles associated with high adherence to dietary recommendations-the Alternative Healthy Eating Index (AHEI) - and the extent to which metabolites associated with AHEI also predict incident CVD. Relations between AHEI score and 80 circulating lipids and metabolites, quantified by nuclear magnetic resonance metabolomics, were examined using linear regression models in the Whitehall II study (n = 4824, 55.9 +/- 6.1 years, 28.0% women) and were replicated in the Cardiovascular Risk in Young Finns Study (n = 1716, 37.7 +/- 5.0 years, 56.3% women). We used Cox models to study associations between metabolites and incident CVD over the 15.8-year follow-up in the Whitehall II study. After adjustment for confounders, higher AHEI score (indicating healthier diet) was associated with higher degree of unsaturation of fatty acids (FA) and higher ratios of polyunsaturated FA, omega-3 and docosahexaenoic acid relative to total FA in both Whitehall II and Young Finns studies. A concordance of associations of metabolites with higher AHEI score and lower CVD risk was observed in Whitehall II. Adherence to healthy diet seems to be associated with specific FA that reduce risk of CVD. en
dc.format.extent 14
dc.language.iso eng
dc.relation.ispartof Scientific Reports
dc.rights cc_by
dc.rights.uri info:eu-repo/semantics/openAccess
dc.subject NUCLEAR-MAGNETIC-RESONANCE
dc.subject CORONARY-HEART-DISEASE
dc.subject WHITEHALL II COHORT
dc.subject FATTY-ACIDS
dc.subject PARTICLE-SIZE
dc.subject EATING INDEX
dc.subject YOUNG FINNS
dc.subject METABOLOMICS
dc.subject WOMEN
dc.subject MEN
dc.subject 3121 General medicine, internal medicine and other clinical medicine
dc.subject 3142 Public health care science, environmental and occupational health
dc.title Association of circulating metabolites with healthy diet and risk of cardiovascular disease : analysis of two cohort studies en
dc.type Article
dc.contributor.organization Clinicum
dc.contributor.organization Department of Public Health
dc.contributor.organization University of Helsinki
dc.description.reviewstatus Peer reviewed
dc.relation.doi https://doi.org/10.1038/s41598-018-26441-1
dc.relation.issn 2045-2322
dc.rights.accesslevel openAccess
dc.type.version publishedVersion

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