Diffusion-weighted magnetic resonance imaging for evaluation of salivary gland function in head and neck cancer patients treated with intensity-modulated radiotherapy

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Loimu , V , Seppälä , T , Kapanen , M , Tuomikoski , L , Nurmi , H , Makitie , A , Tenhunen , M & Saarilahti , K 2017 , ' Diffusion-weighted magnetic resonance imaging for evaluation of salivary gland function in head and neck cancer patients treated with intensity-modulated radiotherapy ' , Radiotherapy and Oncology , vol. 122 , no. 2 , pp. 178-184 . https://doi.org/10.1016/j.radonc.2016.07.008

Title: Diffusion-weighted magnetic resonance imaging for evaluation of salivary gland function in head and neck cancer patients treated with intensity-modulated radiotherapy
Author: Loimu, Venla; Seppälä, Tiina; Kapanen, Mika; Tuomikoski, Laura; Nurmi, Heidi; Makitie, Antti; Tenhunen, Mikko; Saarilahti, Kauko
Other contributor: University of Helsinki, University of Helsinki
University of Helsinki, Department of Oncology
University of Helsinki, University of Helsinki
University of Helsinki, Department of Oncology
University of Helsinki, Clinicum
University of Helsinki, Department of Oncology
University of Helsinki, Department of Oncology





Date: 2017-02
Language: eng
Number of pages: 7
Belongs to series: Radiotherapy and Oncology
ISSN: 0167-8140
DOI: https://doi.org/10.1016/j.radonc.2016.07.008
URI: http://hdl.handle.net/10138/236596
Abstract: Background and purposes: Permanent xerostomia as a result of radiation-induced salivary gland damage remains a common side effect of radiotherapy (RT) of the head and neck. The purpose of this study was to evaluate the usefulness of diffusion-weighted magnetic resonance imaging (DW-MRI) in assessing the post-RT salivary gland function in patients with head and neck cancer (HNC). Materials and methods: In this prospective study, 20 HNC patients scheduled for bilateral neck chemoradiotherapy (CRT) with weekly cisplatin went through diffusion-weighted magnetic resonance imaging (DW-MRI) and salivary gland scintigraphy (SGS) prior to and at a mean of six months after completing the treatment. The changes in apparent diffusion coefficient (ADC) before and after treatment were compared with ejection fraction (EF) measured with SGS and the radiation dose absorbed by the salivary glands. Results: As a result of gustatory stimulation with ascorbic acid, the ADC showed a biphasic response with an initial increase and subsequent decrease. This pattern was seen both before and after RT. Post-RT ADC increased as a function of RT dose absorbed by the salivary glands. A moderate statistical correlation between pre- and post-RT ADCs at rest and EF measured with SGS was found. Conclusions: DW-MRI seems a promising tool for detection of physiological and functional changes in major salivary glands after RT. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
Subject: DW-MRI
IMRT
Salivary glands
Head and neck cancer
Salivary gland scintigraphy
Chemoradiotherapy
GUSTATORY STIMULATION
PAROTID-GLAND
INDUCED XEROSTOMIA
ECHO-PLANAR
COEFFICIENT
THERAPY
MRI
SCINTIGRAPHY
EXPERIENCE
VALUES
3122 Cancers
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